AZI2 and IKBKE

Number of citations of the paper that reports this interaction (PubMedID 17568778)
74

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		AZI2	IKBKE
Description		5-azacytidine induced 2	inhibitor of nuclear factor kappa B kinase subunit epsilon
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Mitochondrial Membrane
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Phosphatase Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Mitotic Cell Cycle I-kappaB Kinase/NF-kappaB Signaling T Cell Activation Dendritic Cell Proliferation Dendritic Cell Differentiation	Protein Phosphorylation Immune Response I-kappaB Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Gene Expression Positive Regulation Of Lipid Storage Peptidyl-serine Phosphorylation Response To Type I Interferon Response To Interferon-beta NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein-containing Complex Assembly MRNA Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Type I Interferon-mediated Signaling Pathway Interleukin-17-mediated Signaling Pathway Cellular Response To Virus
Pathways			SUMOylation of immune response proteins TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs			Fostamatinib
Diseases
GWAS		Cognitive decline (age-related) ( 28078323)	Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Psoriasis ( 28537254) Systemic lupus erythematosus ( 27399966 33272962)
Interacting Genes		13 interacting genes: APBA3 FAM107A IKBKE MIB1 MTPAP N4BP1 RB1CC1 RNF31 TAX1BP1 TBK1 TICAM1 TRAF3 TXLNA	26 interacting genes: AZI2 BIRC2 BIRC3 CDC37 CHUK CSF2 CYLD DAXX DDX3X FKBP5 HSP90AA1 HSP90AB1 IRF3 IRF5 KTN1 MBP MUC1 NFKBIA PTGFR RELA RIPK1 SIKE1 TANK TICAM1 TRIM27 XIAP
Entrez ID		64343	9641
HPRD ID		10577	05442
Ensembl ID		ENSG00000163512	ENSG00000263528
Uniprot IDs		Q9H6S1	A0A075B7B4 Q14164
PDB IDs		5EP6 5Z7G 5Z7L
Enriched GO Terms of Interacting Partners?
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