DNAJC1 and CYP4F2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DNAJC1	CYP4F2
Description		DnaJ heat shock protein family (Hsp40) member C1	cytochrome P450 family 4 subfamily F member 2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane Nuclear Membrane	Cytoplasm Endoplasmic Reticulum Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	ATPase Activator Activity DNA Binding Protein Binding Chaperone Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonic Acid Monooxygenase Activity Arachidonic Acid Epoxygenase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Alkane 1-monooxygenase Activity Heme Binding Leukotriene-B4 20-monooxygenase Activity Arachidonic Acid Omega-hydroxylase Activity Alpha-tocopherol Omega-hydroxylase Activity Tocotrienol Omega-hydroxylase Activity Aromatase Activity 20-hydroxy-leukotriene B4 Omega Oxidase Activity 20-aldehyde-leukotriene B4 20-monooxygenase Activity Docosanoate Omega-hydroxylase Activity
	Biological Process	Regulation Of Translation Protein Folding Negative Regulation Of Proteolysis Regulation Of Protein Secretion Regulation Of Catalytic Activity	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Renal Water Homeostasis Pressure Natriuresis Icosanoid Metabolic Process Leukotriene Metabolic Process Xenobiotic Metabolic Process Blood Coagulation Regulation Of Blood Pressure Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Negative Regulation Of Icosanoid Secretion Positive Regulation Of Icosanoid Secretion Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Menaquinone Catabolic Process Phylloquinone Catabolic Process Vitamin K Catabolic Process Sodium Ion Homeostasis Omega-hydroxylase P450 Pathway
Pathways			Fatty acids Miscellaneous substrates Eicosanoids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33339817) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Essential hypertension (time to event) ( 32589924) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Oily fish consumption ( 32066663) Ovarian cancer ( 23535730) Pork consumption ( 32066663) Raw vegetable consumption ( 32066663) Subcutaneous adipose tissue ( 26480920) Urinary albumin-to-creatinine ratio ( 31511532)	Acenocoumarol maintenance dosage ( 19578179) Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Circulating phylloquinone levels ( 25411281) Metabolite levels ( 23281178) Response to Vitamin E supplementation ( 22437554) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Vitamin E levels ( 21729881) Warfarin maintenance dose ( 20833655 19300499)
Interacting Genes		11 interacting genes: ABHD16A AGTRAP ATP6V0C CMTM7 CYP4F2 HSPA5 ITIH4 PLP2 SERPINA3 TMEM201 TNFRSF10C	37 interacting genes: - AQP6 CHMP2A CPLX4 CREB3 CREB3L1 DNAJC1 EBP ELOVL4 ERGIC3 FAM210B FCER1G GJA8 HSD17B13 JAGN1 LEPROTL1 MMD MTIF3 MUC1 PGRMC2 PLEKHO1 REEP2 REEP4 RETREG3 SCN3B SDHAF2 SLC10A6 SLC17A8 SLC19A3 SLC2A13 THAP4 TLCD4 TM4SF19 TMEM51 TMEM82 TMX2 UBE2I
Entrez ID		64215	8529
HPRD ID		09922	05112
Ensembl ID		ENSG00000136770	ENSG00000186115
Uniprot IDs		Q96KC8	P78329
PDB IDs		2CQQ 2CQR
Enriched GO Terms of Interacting Partners?
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