CYP4F2 and SDHAF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CYP4F2	SDHAF2
Description		cytochrome P450 family 4 subfamily F member 2	succinate dehydrogenase complex assembly factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle	Nucleolus Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonic Acid Monooxygenase Activity Arachidonic Acid Epoxygenase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Alkane 1-monooxygenase Activity Heme Binding Leukotriene-B4 20-monooxygenase Activity Arachidonic Acid Omega-hydroxylase Activity Alpha-tocopherol Omega-hydroxylase Activity Tocotrienol Omega-hydroxylase Activity Aromatase Activity 20-hydroxy-leukotriene B4 Omega Oxidase Activity 20-aldehyde-leukotriene B4 20-monooxygenase Activity Docosanoate Omega-hydroxylase Activity	Protein Binding
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Renal Water Homeostasis Pressure Natriuresis Icosanoid Metabolic Process Leukotriene Metabolic Process Xenobiotic Metabolic Process Blood Coagulation Regulation Of Blood Pressure Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Negative Regulation Of Icosanoid Secretion Positive Regulation Of Icosanoid Secretion Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Menaquinone Catabolic Process Phylloquinone Catabolic Process Vitamin K Catabolic Process Sodium Ion Homeostasis Omega-hydroxylase P450 Pathway	Tricarboxylic Acid Cycle Mitochondrial Electron Transport, Succinate To Ubiquinone Protein Dephosphorylation Negative Regulation Of Epithelial To Mesenchymal Transition Protein-FAD Linkage Mitochondrial Respiratory Chain Complex II Assembly Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Fatty acids Miscellaneous substrates Eicosanoids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Drugs
Diseases
GWAS		Acenocoumarol maintenance dosage ( 19578179) Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Circulating phylloquinone levels ( 25411281) Metabolite levels ( 23281178) Response to Vitamin E supplementation ( 22437554) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Vitamin E levels ( 21729881) Warfarin maintenance dose ( 20833655 19300499)
Interacting Genes		37 interacting genes: - AQP6 CHMP2A CPLX4 CREB3 CREB3L1 DNAJC1 EBP ELOVL4 ERGIC3 FAM210B FCER1G GJA8 HSD17B13 JAGN1 LEPROTL1 MMD MTIF3 MUC1 PGRMC2 PLEKHO1 REEP2 REEP4 RETREG3 SCN3B SDHAF2 SLC10A6 SLC17A8 SLC19A3 SLC2A13 THAP4 TLCD4 TM4SF19 TMEM51 TMEM82 TMX2 UBE2I	6 interacting genes: CCDC90B CYP4F2 EEF1A1 ELP1 IMMT SEC22A
Entrez ID		8529	54949
HPRD ID		05112	07915
Ensembl ID		ENSG00000186115	ENSG00000167985
Uniprot IDs		P78329	Q9NX18
PDB IDs			6VAX
Enriched GO Terms of Interacting Partners?
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