ERAP2 and CNTN4

		ERAP2	CNTN4
Description		endoplasmic reticulum aminopeptidase 2	contactin 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane	Extracellular Region Plasma Membrane Axon Anchored Component Of Membrane
	Molecular Function	Endopeptidase Activity Aminopeptidase Activity Metallopeptidase Activity Zinc Ion Binding Peptide Binding Metalloaminopeptidase Activity	Cell-cell Adhesion Mediator Activity
	Biological Process	Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Proteolysis Signal Transduction Regulation Of Blood Pressure Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Peptide Catabolic Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Nervous System Development Axonogenesis Axon Guidance Axonal Fasciculation Brain Development Neuron Projection Development Negative Regulation Of Neuron Differentiation Regulation Of Synaptic Plasticity Dendrite Self-avoidance
Pathways		Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Ankylosing spondylitis ( 23749187) Arthritis (juvenile idiopathic) ( 33106285) Aspartate aminotransferase levels ( 33547301) Birdshot chorioretinopathy ( 24957906) Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Diastolic blood pressure night-to-day ratio in hypertension ( 29973135) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Pediatric autoimmune diseases ( 26301688) Urate levels (BMI interaction) ( 25811787)	Acenocoumarol maintenance dosage ( 19578179) Amyotrophic lateral sclerosis ( 19451621) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atypical femoral fracture in phosphonate treatment ( 31006051) Autism spectrum disorder or schizophrenia ( 28540026) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood pressure ( 17903302) Blood pressure (smoking interaction) ( 25189868) Blood protein levels ( 30072576 29875488) Body mass index (change over time) in chronic obstructive pulmonary disease ( 28044437) Brain connectivity ( 23471985) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime sleep phenotypes ( 27126917) Diisocyanate-induced asthma ( 25918132) Disease progression in age-related macular degeneration ( 29346644) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels in HIV infection ( 33109212) High density lipoprotein cholesterol levels ( 31647587 34074324) High myopia ( 32428537) Intake of total sugars ( 31005972) Intelligence ( 22449649) Metabolite levels ( 23823483) Middle childhood and early adolescence aggressive behavior ( 26087016) Night sleep phenotypes ( 27126917) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to aripiprazole in schizophrenia ( 29503163) Restless legs syndrome ( 29029846) Schizophrenia ( 28991256 25056061 29483656 30285260 26198764) Sensorimotor dexterity ( 31596458) Serum immune biomarker levels ( 32066700) Serum uric acid levels ( 24379826) Thiopurine-induced pancreatitis in inflammatory bowel disease ( 29923122) Total ventricular volume ( 21116278) White blood cell count (basophil) ( 27863252)
Interacting Genes		1 interacting genes: CNTN4	7 interacting genes: BARD1 BRCA1 CNTN6 ERAP2 GHRL PRICKLE4 TBCA
Entrez ID		64167	152330
HPRD ID		14306	16239
Ensembl ID		ENSG00000164308	ENSG00000144619
Uniprot IDs		B2R769 Q6P179	Q8IWV2
PDB IDs		3SE6 4E36 4JBS 5AB0 5AB2 5CU5 5J6S 5K1V 6EA4
Enriched GO Terms of Interacting Partners?
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