ERAP2

Description		endoplasmic reticulum aminopeptidase 2
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane
	Molecular Function	Endopeptidase Activity Aminopeptidase Activity Metallopeptidase Activity Zinc Ion Binding Peptide Binding Metalloaminopeptidase Activity
	Biological Process	Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Proteolysis Signal Transduction Regulation Of Blood Pressure Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Peptide Catabolic Process
Pathways		Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Ankylosing spondylitis ( 23749187) Arthritis (juvenile idiopathic) ( 33106285) Aspartate aminotransferase levels ( 33547301) Birdshot chorioretinopathy ( 24957906) Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Diastolic blood pressure night-to-day ratio in hypertension ( 29973135) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Pediatric autoimmune diseases ( 26301688) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		1 interacting genes: CNTN4
Entrez ID		64167
HPRD ID		14306
Ensembl ID		ENSG00000164308
Uniprot IDs		B2R769 Q6P179
PDB IDs		3SE6 4E36 4JBS 5AB0 5AB2 5CU5 5J6S 5K1V 6EA4
Enriched GO Terms of Interacting Partners?
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