DMRTB1 and EYA2

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1103

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DMRTB1	EYA2
Description		DMRT like family B with proline rich C-terminal 1	EYA transcriptional coactivator and phosphatase 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Mitochondrion Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding	Magnesium Ion Binding Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Germ Cell Development Sex Differentiation	DNA Repair Mesodermal Cell Fate Specification Striated Muscle Tissue Development Histone Dephosphorylation Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of DNA Repair Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Outer Membrane Permeabilization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Cerebrospinal fluid AB1-42 levels ( 28247064) Response to statin therapy ( 20339536)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 31361310) Asthma ( 32296059) Body fat percentage and triglycerides (pairwise) ( 33619380) Body shape index ( 34021172) Brain volume in infants (intracranial brain volume) ( 28763065) Coffee consumption ( 31046077) Fasting insulin ( 34059833) FEV1 ( 30804560) Glaucoma (primary open-angle) ( 33627673) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Lung function (FVC) ( 30061609 30804560) Non-del(5q) myelodysplastic syndromes ( 31738830) Peak expiratory flow ( 30804560) Reticulocyte count ( 32888494) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Triglyceride levels ( 32203549 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes ( 30054458 30297969) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		40 interacting genes: C1orf94 CCND3 CDKN2D CTBP1 CTBP2 EWSR1 EXOSC1 EXOSC5 EYA2 FXR2 HNRNPUL1 IL16 INCA1 KRTAP19-5 KRTAP19-6 KRTAP21-2 KRTAP8-1 LENG8 NCKIPSD NEDD9 NIF3L1 PARD6G PEF1 PKP2 PRMT2 QKI RAMAC RBFOX1 RBFOX2 RBM14 RBPMS RPA2 SH3RF1 SLAIN1 SORBS3 TENT5A TLE5 TOX TSG101 VASP	36 interacting genes: AATK BAG3 CATSPER1 CDK18 DMRTB1 DTX2 DUSP21 ENKD1 FAM214B GNAI2 GNAZ HGS IQUB LGALS4 LOX MED25 PATZ1 PAX9 PIN1 POGZ RBPMS RFX2 ROR2 SIX1 SIX4 SNRPC SPG21 SUOX TEKT4 TEKT5 TFG TLE5 TRAF4 TRAPPC6A TSSK3 VPS37C
Entrez ID		63948	2139
HPRD ID		16828	09041
Ensembl ID		ENSG00000143006	ENSG00000064655
Uniprot IDs		I6L9A0 Q96MA1	E7ETN2 O00167
PDB IDs			3GEB 3HB0 3HB1 4EGC 5ZMA
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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