SDHD and GPR35

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		SDHD	GPR35
Description		succinate dehydrogenase complex subunit D	G protein-coupled receptor 35
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Envelope Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex II, Succinate Dehydrogenase Complex (ubiquinone) Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Electron Transfer Activity Heme Binding Metal Ion Binding Ubiquinone Binding	G Protein-coupled Receptor Activity C-X-C Chemokine Receptor Activity
	Biological Process	Tricarboxylic Acid Cycle Mitochondrial Electron Transport, Succinate To Ubiquinone	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Chemokine-mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Neuronal Action Potential
Pathways		Respiratory electron transport Citric acid cycle (TCA cycle)	Class A/1 (Rhodopsin-like receptors)
Drugs		Hexachlorophene 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Ubiquinone Q1	Furosemide Pyrantel Kynurenic Acid
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Waist circumference adjusted for body mass index ( 34021172)	Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 25489960) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		5 interacting genes: F2RL1 GPR35 MTNR1B RHBDD2 SLC13A1	59 interacting genes: ABHD14A ADGRB1 AIG1 APH1A ATP1A1 ATP2C1 AUP1 B3GAT3 B4GALT2 BNIP1 CANX CD81 CH25H CMTM3 CRHR2 ERGIC3 FLRT1 FTH1 GHITM GJC2 GPR146 GPR161 HLA-A KCNJ4 KDELR1 LSS MCOLN1 MSMO1 NPC1 NSDHL OSTC PLD3 PLLP PLXDC1 PPP1R3F RTN3 RTN4 SCARB1 SDHD SELENOK SLC15A4 SLC2A1 SLC31A2 SLC37A1 SLC37A4 SLC45A4 SLC8A2 SLC9A7 SPART SYNGR2 SYT11 TMEM161A TMEM94 TSPAN7 VPS25 VTI1B YIF1B ZDHHC3 ZFAND1
Entrez ID		6392	2859
HPRD ID		04069	16003
Ensembl ID		ENSG00000204370	ENSG00000178623
Uniprot IDs		A0A0S2Z4H7 A0A0S2Z4J3 O14521	A8K2J1 B2RA17 Q9HC97
PDB IDs
Enriched GO Terms of Interacting Partners?
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