GPR35 and NPC1

  • Number of citations of the paper that reports this interaction (PubMedID 28298427)
  • 23
  • Data Source:
  • BioGRID (two hybrid)

GPR35

NPC1

Description G protein-coupled receptor 35 NPC intracellular cholesterol transporter 1
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Ankylosing spondylitis ( 23749187)
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Crohn's disease ( 25489960)
  • Granulocyte percentage of myeloid white cells ( 27863252)
  • Inflammatory bowel disease ( 28067908 23128233)
  • Monocyte count ( 32888494 27863252)
  • Monocyte percentage of white cells ( 32888494 27863252)
  • Pediatric autoimmune diseases ( 26301688)
  • Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403)
  • Ulcerative colitis ( 28067908 21297633)
Interacting Genes 59 interacting genes: ABHD14A ADGRB1 AIG1 APH1A ATP1A1 ATP2C1 AUP1 B3GAT3 B4GALT2 BNIP1 CANX CD81 CH25H CMTM3 CRHR2 ERGIC3 FLRT1 FTH1 GHITM GJC2 GPR146 GPR161 HLA-A KCNJ4 KDELR1 LSS MCOLN1 MSMO1 NPC1 NSDHL OSTC PLD3 PLLP PLXDC1 PPP1R3F RTN3 RTN4 SCARB1 SDHD SELENOK SLC15A4 SLC2A1 SLC31A2 SLC37A1 SLC37A4 SLC45A4 SLC8A2 SLC9A7 SPART SYNGR2 SYT11 TMEM161A TMEM94 TSPAN7 VPS25 VTI1B YIF1B ZDHHC3 ZFAND1 6 interacting genes: BUD31 FURIN GPR35 MC4R MTDH VPS4A
Entrez ID 2859 4864
HPRD ID 16003 09622
Ensembl ID ENSG00000178623 ENSG00000141458
Uniprot IDs A8K2J1 B2RA17 Q9HC97 O15118
PDB IDs 3GKH 3GKI 3GKJ 3JD8 5F18 5F1B 5HNS 5JNX 5KWY 5U73 5U74 6UOX 6W5R 6W5S 6W5T 6W5U 6W5V
Enriched GO Terms of Interacting Partners?
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