ELMO2 and DOCK4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ELMO2	DOCK4
Description		engulfment and cell motility 2	dedicator of cytokinesis 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane	Nucleolus Golgi Apparatus Cytosol Plasma Membrane Membrane Stereocilium Stereocilium Bundle
	Molecular Function	Protein Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding PDZ Domain Binding Receptor Tyrosine Kinase Binding Small GTPase Binding
	Biological Process	Phagocytosis Apoptotic Process Actin Filament Organization Cell Motility Cell Chemotaxis Cell-cell Adhesion	Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity Cell Chemotaxis Negative Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RHOG GTPase cycle FCGR3A-mediated phagocytosis	RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Body mass index (change over time) ( 25378290) C-reactive protein and white blood cell count ( 22788528) Migraine ( 27322543) Refractive astigmatism ( 30306274) Refractive error ( 32231278) Response to fenofibrate ( 22890011) Total intracranial volume ( 31530798)
Interacting Genes		3 interacting genes: DOCK1 DOCK4 RHOG	4 interacting genes: ELMO2 FASLG GRB2 RNF115
Entrez ID		63916	9732
HPRD ID		12103	07407
Ensembl ID		ENSG00000062598	ENSG00000128512
Uniprot IDs		Q96JJ3	Q8N1I0
PDB IDs		6IDX 6IE1
Enriched GO Terms of Interacting Partners?
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