PRDM1 and EXOSC3

		PRDM1	EXOSC3
Description		PR/SET domain 1	exosome component 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Histone Deacetylase Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Morphogenesis Of A Branching Structure Kidney Development Maternal Placenta Development Adaptive Immune Response Heart Valve Development Ventricular Septum Development Regulation Of Transcription By RNA Polymerase II Germ Cell Development Post-embryonic Development Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Methylation Regulation Of Natural Killer Cell Differentiation Regulation Of Extrathymic T Cell Differentiation Aorta Development Regulation Of Cell Population Proliferation Eye Photoreceptor Cell Development Innate Immune Response Cell Fate Commitment Artery Morphogenesis Regulation Of NK T Cell Differentiation Intestinal Epithelial Cell Development Trophoblast Giant Cell Differentiation Coronary Vasculature Development Sebum Secreting Cell Proliferation	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways		Regulation of TP53 Expression STAT3 nuclear events downstream of ALK signaling	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463) Diastolic blood pressure ( 30224653) Monobrow ( 27182965) Multiple myeloma ( 27363682) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 23273568 33272962 26502338 28714469 19838193 19838195) Systemic sclerosis ( 28314753) Triglyceride levels ( 32203549)
Interacting Genes		16 interacting genes: ATXN1 EXOSC3 FRK H1-1 H3C15 HPGD IKZF3 IRF4 KDM1A MAD2L1BP MAN1A1 PIAS1 TLE1 TLE2 TLE5 UTP18	11 interacting genes: APP ATP5F1D CDK5RAP1 EXOSC4 EXOSC5 EXOSC9 KHSRP MPHOSPH6 PRDM1 PRDX1 TSR2
Entrez ID		639	51010
HPRD ID		04572	16220
Ensembl ID		ENSG00000057657	ENSG00000107371
Uniprot IDs		A0A3B3IU23 B4DW27 O75626 Q5T4E8	Q9NQT5 Q9NYS3
PDB IDs		3DAL	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?