PRDM1 and MAN1A1

		PRDM1	MAN1A1
Description		PR/SET domain 1	mannosidase alpha class 1A member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Membrane Integral Component Of Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Histone Deacetylase Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding Mannosidase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Morphogenesis Of A Branching Structure Kidney Development Maternal Placenta Development Adaptive Immune Response Heart Valve Development Ventricular Septum Development Regulation Of Transcription By RNA Polymerase II Germ Cell Development Post-embryonic Development Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Methylation Regulation Of Natural Killer Cell Differentiation Regulation Of Extrathymic T Cell Differentiation Aorta Development Regulation Of Cell Population Proliferation Eye Photoreceptor Cell Development Innate Immune Response Cell Fate Commitment Artery Morphogenesis Regulation Of NK T Cell Differentiation Intestinal Epithelial Cell Development Trophoblast Giant Cell Differentiation Coronary Vasculature Development Sebum Secreting Cell Proliferation	Carbohydrate Metabolic Process Protein Glycosylation N-glycan Processing Ubiquitin-dependent ERAD Pathway Protein Targeting To ER Golgi Apparatus Mannose Trimming Mannose Trimming Involved In Glycoprotein ERAD Pathway
Pathways		Regulation of TP53 Expression STAT3 nuclear events downstream of ALK signaling	Intra-Golgi traffic Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463) Diastolic blood pressure ( 30224653) Monobrow ( 27182965) Multiple myeloma ( 27363682) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 23273568 33272962 26502338 28714469 19838193 19838195) Systemic sclerosis ( 28314753) Triglyceride levels ( 32203549)	Adult body size ( 32376654) Fasting glucose ( 33381925) Metabolite levels ( 23823483) Neonatal white matter microstructure ( 33009551) Spontaneous preterm birth (preterm birth) ( 25599974) Weight ( 28552196)
Interacting Genes		16 interacting genes: ATXN1 EXOSC3 FRK H1-1 H3C15 HPGD IKZF3 IRF4 KDM1A MAD2L1BP MAN1A1 PIAS1 TLE1 TLE2 TLE5 UTP18	1 interacting genes: PRDM1
Entrez ID		639	4121
HPRD ID		04572	05066
Ensembl ID		ENSG00000057657	ENSG00000111885
Uniprot IDs		A0A3B3IU23 B4DW27 O75626 Q5T4E8	P33908
PDB IDs		3DAL
Enriched GO Terms of Interacting Partners?
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