CCL22 and HERC3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		CCL22	HERC3
Description		C-C motif chemokine ligand 22	HECT and RLD domain containing E3 ubiquitin protein ligase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytosol Cytoplasmic Vesicle
	Molecular Function	Protein Binding Chemokine Activity CCR Chemokine Receptor Binding	Ubiquitin-protein Transferase Activity
	Biological Process	Monocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Protein Ubiquitination
Pathways		Chemokine receptors bind chemokines Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma ( 32296059) Blood protein levels ( 30072576 29875488) Multiple sclerosis ( 24076602) Systemic lupus erythematosus ( 33272962 28714469)	Body shape index ( 34021172) Hair greying ( 26926045) Post bronchodilator FEV1/FVC ratio ( 26634245) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		11 interacting genes: AQP6 CCL14 CCL19 CCR4 CRYAB DPP4 GCLC HERC3 NLGN4X PF4V1 VCAM1	13 interacting genes: CCL22 CD33 HERC6 NME2 SRPK2 TK1 TRIM14 UBA52 UBC UBE2D1 UBE2L3 UBQLN1 UBQLN2
Entrez ID		6367	8916
HPRD ID		04263	16093
Ensembl ID		ENSG00000102962	ENSG00000138641
Uniprot IDs		O00626	B4DK41 Q15034
PDB IDs
Enriched GO Terms of Interacting Partners?
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