ATXN7 and LTBP4

Number of citations of the paper that reports this interaction (PubMedID 21078624)
26

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ATXN7	LTBP4
Description		ataxin 7	latent transforming growth factor beta binding protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Microtubule Cytoskeleton Nuclear Matrix	Microfibril Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding	Transforming Growth Factor Beta-activated Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Transforming Growth Factor Beta Binding
	Biological Process	Microtubule Cytoskeleton Organization Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Histone Deubiquitination	Regulation Of Cell Growth Protein Folding Transforming Growth Factor Beta Receptor Signaling Pathway Multicellular Organism Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Proteolysis Growth Hormone Secretion Regulation Of Cell Differentiation
Pathways		HATs acetylate histones Ub-specific processing proteases	Molecules associated with elastic fibres
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Red cell distribution width ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30054458)	Appendicular lean mass ( 33097823) Carotid intima media thickness (mean) ( 31801372) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1/FVC) ( 26635082 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Red blood cell count ( 32888494)
Interacting Genes		65 interacting genes: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CPOX CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GNAT1 GOLGA2 GOLGA3 GPRASP1 GRN IMPDH2 ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PDHB PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SERINC3 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 SYNJ2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 USP22 VCP VWF	16 interacting genes: ATN1 ATXN7 CACNA1A CRKL CRY1 CTDSP1 FBLN1 FRAT1 GFI1B HOXA1 ITSN2 MBD1 NUFIP2 RAC1 SHANK3 TGFB1
Entrez ID		6314	8425
HPRD ID		06365	05274
Ensembl ID		ENSG00000163635	ENSG00000090006
Uniprot IDs		O15265 Q9UPD8	A0A0C4DH07 B3KXY6 Q8N2S1
PDB IDs		2KKR
Enriched GO Terms of Interacting Partners?
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