ATXN7 and CRIM1

Number of citations of the paper that reports this interaction (PubMedID 21078624)
26

Data Source:
BioGRID (two hybrid)

		ATXN7	CRIM1
Description		ataxin 7	cysteine rich transmembrane BMP regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Microtubule Cytoskeleton Nuclear Matrix	Extracellular Region Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Serine-type Endopeptidase Inhibitor Activity Insulin-like Growth Factor-activated Receptor Activity Insulin-like Growth Factor Binding PDZ Domain Binding
	Biological Process	Microtubule Cytoskeleton Organization Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Histone Deubiquitination	Nervous System Development Negative Regulation Of Endopeptidase Activity Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Insulin-like Growth Factor Receptor Signaling Pathway
Pathways		HATs acetylate histones Ub-specific processing proteases
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Red cell distribution width ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30054458)	Adult body size ( 32376654) Anthropometric traits ( 19260139) Bone mineral density (total hip) ( 29883787) Central corneal thickness ( 32528159) Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Height ( 25282103 25429064 31562340 33713608) Hip circumference adjusted for BMI ( 34021172) IgE levels in asthmatics ( 23967269) Mean reticulocyte volume ( 32888494) Morning person ( 30696823) QRS duration ( 27577874 30012220) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		65 interacting genes: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CPOX CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GNAT1 GOLGA2 GOLGA3 GPRASP1 GRN IMPDH2 ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PDHB PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SERINC3 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 SYNJ2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 USP22 VCP VWF	3 interacting genes: ATXN7 CACNA1A MTDH
Entrez ID		6314	51232
HPRD ID		06365	08392
Ensembl ID		ENSG00000163635	ENSG00000150938
Uniprot IDs		O15265 Q9UPD8	Q9NZV1
PDB IDs		2KKR
Enriched GO Terms of Interacting Partners?
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