SARS1 and PTPN22

		SARS1	PTPN22
Description		seryl-tRNA synthetase 1	protein tyrosine phosphatase non-receptor type 22
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Nucleus Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	TRNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Binding Serine-tRNA Ligase Activity Protein Binding ATP Binding Enzyme Binding Protein Homodimerization Activity	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Phosphatase Activity SH3 Domain Binding Kinase Binding Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Translation Seryl-tRNA Aminoacylation TRNA Processing Negative Regulation Of Angiogenesis Selenocysteinyl-tRNA(Sec) Biosynthetic Process Negative Regulation Of Vascular Endothelial Growth Factor Production	Positive Regulation Of Defense Response To Virus By Host Protein Dephosphorylation Autophagy Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-gamma Production Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Peptidyl-tyrosine Dephosphorylation Phosphoanandamide Dephosphorylation Negative Regulation Of JUN Kinase Activity Regulation Of Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Muramyl Dipeptide Positive Regulation Of Granzyme B Production Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of P38MAPK Cascade Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Pathways		Selenocysteine synthesis Cytosolic tRNA aminoacylation	Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse
Drugs		Serine
Diseases
GWAS			Alopecia areata ( 25608926) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Arthritis (juvenile idiopathic) ( 33106285) Autoimmune thyroid disease ( 32581359) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Autoimmune traits (pleiotropy) ( 30572963) Breast cancer ( 23535729) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 21102463 23128233) Giant cell arteritis ( 25817017) Granulocyte count ( 27863252) Graves' disease ( 22922229) Gut microbiota (bacterial taxa) ( 27694959) Hashimoto thyroiditis ( 22922229) Hodgkin's lymphoma ( 30194254) Hypothyroidism ( 27182965 22493691) Idiopathic inflammatory myopathy ( 26362759) IgM levels ( 28628107) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Late-onset myasthenia gravis ( 26562150) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083) Lymphocyte counts ( 32888494 27863252) Medication use (drugs used in diabetes) ( 31015401) Medication use (thyroid preparations) ( 31015401) Myasthenia gravis ( 23055271) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Obesity-related traits ( 23251661) Pediatric autoimmune diseases ( 26301688) Polymyositis ( 26362759) Rheumatoid arthritis ( 24449572 17804836 30891314 30423114 18794853 17554300 21156761 30572963 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338 28714469 19838195) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Thyroid peroxidase antibody levels ( 24586183) Type 1 diabetes ( 21829393 17632545 25751624 19430480 17554260 17554300 30572963 18978792) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Vitiligo ( 20410501 27723757) White blood cell count ( 32888494 27863252)
Interacting Genes		8 interacting genes: LINC01554 OGT POT1 PTPN22 SUMO2 TERF1 TINF2 TRS-AGA2-3	18 interacting genes: CBL CD247 CD3E CLK1 CSK EGFR GRB2 GSTP1 HMGCS2 ING4 LCK NOTCH2 PRKCD SARS1 SRPK2 VAV1 WARS2 ZAP70
Entrez ID		6301	26191
HPRD ID		09605	06100
Ensembl ID		ENSG00000031698	ENSG00000134242
Uniprot IDs		P49591 Q0VGA5 Q5T5C7	B4DZW8 G3K0T4 Q9Y2R2
PDB IDs		3VBB 4L87 4RQE 4RQF	2P6X 2QCJ 2QCT 3BRH 3H2X 3OLR 3OMH 4J51
Enriched GO Terms of Interacting Partners?
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