MRPL12 and CBX3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MRPL12	CBX3
Description		mitochondrial ribosomal protein L12	chromobox 3
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Euchromatin Heterochromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Pericentric Heterochromatin Spindle RNA Polymerase II Transcription Regulator Complex Site Of DNA Damage
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	Transcription Coregulator Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Mitochondrial Transcription Translation Positive Regulation Of Transcription, DNA-templated	Chromatin Remodeling Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated Rhythmic Process
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Refractive error ( 32231278) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)	Metabolite levels ( 23823483) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		25 interacting genes: CBX3 COX6A2 EFCAB2 EFEMP2 EXOC3L2 FBLN1 KRTAP10-1 MAPRE3 MICOS10-NBL1 MORF4L1 MORF4L2 NBL1 NTAQ1 NTM OLIG1 POLR1D PPP1R16A RARG SAT1 SEPTIN1 SMG6 TMEM51 TRIM59 TXNDC9 ZNF76	44 interacting genes: ADAMTSL4 ADNP2 ARL5A ATXN7L2 AURKA AURKB BARD1 CACNB4 CBX1 CBX5 CDC42 DNMT3B DSN1 GDF15 H1-4 H3-4 H3C1 H4C1 HECW2 HIPK2 HTR2C KLF11 L3MBTL1 LAP3 LBR LIG1 MGA MIS12 MKI67 MRPL12 NSD3 PIM1 PRR14 RAD54L2 SP100 STK16 TAF4 TRIM24 TRIM28 VHL ZNF10 ZNF280C ZNF280D ZNF496
Entrez ID		6182	11335
HPRD ID		03849	05130
Ensembl ID		ENSG00000262814	ENSG00000122565
Uniprot IDs		P52815	A4D177 Q13185
PDB IDs		6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG	2L11 3DM1 3KUP 3TZD 5T1I 6HW2
Enriched GO Terms of Interacting Partners?
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