EDA2R and EDA

Number of citations of the paper that reports this interaction (PubMedID 11039935)
61

Data Source:
HPRD (in vitro)

		EDA2R	EDA
Description		ectodysplasin A2 receptor	ectodysplasin A
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Collagen Trimer Extracellular Space Endoplasmic Reticulum Membrane Lipid Droplet Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Apical Part Of Cell
	Molecular Function	Tumor Necrosis Factor-activated Receptor Activity Protein Binding Signaling Receptor Activity	Signaling Receptor Binding Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Death Receptor Agonist Activity Receptor Ligand Activity
	Biological Process	Epidermis Development Ectodermal Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Immune Response Cell-matrix Adhesion Signal Transduction Gene Expression Positive Regulation Of Gene Expression Cell Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pigmentation Animal Organ Development Positive Regulation Of NF-kappaB Transcription Factor Activity Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		TNFs bind their physiological receptors	TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Balding ( 26926045) Male-pattern baldness ( 27182965 22032556 28196072)	Male-pattern baldness ( 30573740) Metabolite levels ( 23823483) Monobrow ( 27182965) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Tooth agenesis (maxillary lateral incisors) ( 29364747)
Interacting Genes		17 interacting genes: AGR3 ATP6V0C C1QB CASP8 CEBPE EDA FADD GIMAP5 JAGN1 NKG7 PLP1 SGTA STRIT1 SUFU TMEM262 TRAF3 TRAF6	24 interacting genes: ATP6V0C CTXN3 CYB561 DOLK EDA2R EDAR EMP1 EMP3 FURIN GIMAP5 LEPROTL1 LPAR3 MAL MS4A13 NIPAL3 OSTC OSTCP1 PLN PMP22 SEC22A SLC38A7 TMEM42 TMEM50B TMEM60
Entrez ID		60401	1896
HPRD ID		02230	02347
Ensembl ID		ENSG00000131080	ENSG00000158813
Uniprot IDs		B2RBZ9 B4DQY6 Q9HAV5	A0A0U5J797 Q92838
PDB IDs			1RJ7 1RJ8
Enriched GO Terms of Interacting Partners?
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