RGS7 and GNAQ

Number of citations of the paper that reports this interaction (PubMedID 12670932)
17

Data Source:
HPRD (in vivo, in vitro)

		RGS7	GNAQ
Description		regulator of G protein signaling 7	G protein subunit alpha q
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GO Annotations	Cellular Component	Cytosol Plasma Membrane	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Golgi Apparatus Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Synapse Extracellular Exosome
	Molecular Function	GTPase Activity GTPase Activator Activity G-protein Beta-subunit Binding	G Protein-coupled Receptor Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity	Action Potential Negative Regulation Of Protein Kinase Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Blood Coagulation Phototransduction, Visible Light Entrainment Of Circadian Clock Protein Stabilization Regulation Of Canonical Wnt Signaling Pathway
Pathways		G alpha (i) signalling events G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases
GWAS		Chronotype ( 30696823) Diastolic blood pressure ( 29208002) Ischemic stroke (cardioembolic) ( 29531354) Longevity (90 years and older) ( 25199915) Major depressive disorder ( 27479909) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Western dietary pattern ( 28644415)	Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		17 interacting genes: CHRM1 CHRM2 CHRM3 CHRM5 GNAI1 GNAI3 GNAO1 GNAQ GNAZ GNB5 MSX1 PKD1 PRKCA SDCCAG8 SNAPIN YWHAB YWHAQ	48 interacting genes: ADHFE1 ADRA1B AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRK2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1
Entrez ID		6000	2776
HPRD ID		03948	02998
Ensembl ID		ENSG00000182901	ENSG00000156052
Uniprot IDs		B7Z223 B7Z257 P49802	A0A024R240 P50148
PDB IDs		2A72 2D9J	6VU5
Enriched GO Terms of Interacting Partners?
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