RDH5 and FDX1

		RDH5	FDX1
Description		retinol dehydrogenase 5	ferredoxin 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Integral Component Of Membrane	Mitochondrion Mitochondrial Matrix
	Molecular Function	NAD-retinol Dehydrogenase Activity Protein Homodimerization Activity Androsterone Dehydrogenase Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity	Iron Ion Binding Electron Transfer Activity 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Retinoid Metabolic Process Visual Perception Steroid Metabolic Process Retinol Metabolic Process Response To Stimulus	Steroid Biosynthetic Process Cholesterol Metabolic Process Electron Transport Chain Hormone Biosynthetic Process Cellular Response To CAMP Cellular Response To Forskolin
Pathways		Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) RA biosynthesis pathway	Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes AICSR
Drugs		NADH Vitamin A	Mitotane
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) High myopia ( 31816047) Macular thickness ( 30535121) Myopia ( 27182965) Refractive error ( 23396134) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Cognitive function ( 24684796) Coronary artery disease ( 32469254) Serum metabolite levels ( 33031748)
Interacting Genes		5 interacting genes: FDX1 NAB2 ORC4 RGR RLBP1	12 interacting genes: BIRC2 BIRC3 CNTN5 CORO2A CYCS CYP11A1 CYP11B2 FDXR LILRB2 PBRM1 PRKAB2 RDH5
Entrez ID		5959	2230
HPRD ID		03370	00059
Ensembl ID		ENSG00000135437	ENSG00000137714
Uniprot IDs		A0A024RB18 Q92781	P10109
PDB IDs			3N9Y 3N9Z 3NA0 3NA1 3P1M
Enriched GO Terms of Interacting Partners?
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