PLEKHA1 and ATE1

		PLEKHA1	ATE1
Description		pleckstrin homology domain containing A1	arginyltransferase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Extracellular Exosome	Nucleus Cytoplasm
	Molecular Function	Protein Binding Lipid Binding PDZ Domain Binding Phosphatidylinositol-3,4-bisphosphate Binding	Arginyltransferase Activity Protein Binding
	Biological Process	Luteinization Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Post-embryonic Development Phosphatidylinositol 3-kinase Signaling Ruffle Organization Leydig Cell Differentiation Multicellular Organism Growth Establishment Of Protein Localization Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis B Cell Receptor Signaling Pathway Negative Regulation Of Protein Kinase B Signaling Roof Of Mouth Development Face Morphogenesis Cellular Response To Hydrogen Peroxide	Proteasomal Protein Catabolic Process Protein Arginylation
Pathways		Synthesis of PIPs at the plasma membrane
Drugs		Citric acid
Diseases
GWAS		Age-related macular degeneration ( 23577725 23536807) Age-related macular degeneration (extreme sampling) ( 23577725) Autoimmune thyroid disease ( 32581359) Birth weight ( 31043758 27680694) Central corneal thickness ( 32528159) Femoral neck bone mineral density ( 29499414) Height ( 31562340 20189936) Hip circumference adjusted for BMI ( 34021172) Medication use (thyroid preparations) ( 31015401) Offspring birth weight ( 31043758) Refractive error ( 32231278) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 28566273 24509480 30054458 30297969 32499647 30718926 28869590)	Chronotype ( 30696823)
Interacting Genes		9 interacting genes: ATE1 CLDN14 CRKL FBXO7 MPDZ PLEKHA2 PTPN13 SH3BP4 SNTG1	14 interacting genes: ABRAXAS2 ACADSB ALCAM CTBP2 FAM53B INTS8 NEDD8 NSMCE4A NTAN1 NUP188 PLEKHA1 RBM10 SUV39H1 TIMM17B
Entrez ID		59338	11101
HPRD ID		09686	06979
Ensembl ID		ENSG00000107679	ENSG00000107669
Uniprot IDs		B3KQL5 Q5RGS4 Q9HB21	B3KWA3 B4DK25 B4E107 F5GXE4 F8WAC9 O95260
PDB IDs		1EAZ
Enriched GO Terms of Interacting Partners?
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