RAC3 and PCNT

		RAC3	PCNT
Description		Rac family small GTPase 3	pericentrin
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Cell Cortex Endomembrane System Lamellipodium Growth Cone Cytoplasmic Vesicle Filamentous Actin Cell Projection Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery	Centrosome Centriole Cytosol Microtubule Membrane Centriolar Satellite
	Molecular Function	GTPase Activity G Protein Activity Protein Binding GTP Binding Protein Kinase Binding Calcium-dependent Protein Binding	Protein Binding Calmodulin Binding Molecular Adaptor Activity
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Regulation Of Neuron Maturation Wnt Signaling Pathway Cerebral Cortex GABAergic Interneuron Development Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Intracellular Signal Transduction Homeostasis Of Number Of Cells Within A Tissue Neuromuscular Process Controlling Balance Synaptic Transmission, GABAergic Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Signal Transduction Cilium Assembly Positive Regulation Of Intracellular Protein Transport
Pathways		PCP/CE pathway RAC3 GTPase cycle	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Heel bone mineral density ( 30598549) Pre-treatment viral load in HIV-1 infection ( 31219150) S100 calcium-binding protein levels ( 33227023) Treatment resistant depression ( 30468137)
Interacting Genes		11 interacting genes: ANKRD11 AR ARFIP2 ARHGDIA ARHGDIB CIB1 ESR1 HDAC7 HNF1A NRBP1 PCNT	21 interacting genes: AKAP9 CALM1 CALM2 CCP110 CDK12 CEP55 COL6A1 DISC1 HPRT1 NDUFV3 PCM1 PDE9A PFKL PKNOX1 RAC3 S100B SH3BGR TP53BP1 TUBG1 TUBGCP2 TUBGCP3
Entrez ID		5881	5116
HPRD ID		03629	05804
Ensembl ID		ENSG00000169750	ENSG00000160299
Uniprot IDs		P60763	O95613
PDB IDs		2C2H 2G0N 2IC5 2OV2 2QME 6TM1
Enriched GO Terms of Interacting Partners?
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