SNX6 and SNX4

Number of citations of the paper that reports this interaction (PubMedID 11279102)
47

Data Source:
HPRD (in vitro, in vivo)

		SNX6	SNX4
Description		sorting nexin 6	sorting nexin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Retromer Complex Retromer, Tubulation Complex Early Endosome Membrane Tubular Endosome	Cytoplasm Cytoplasmic Dynein Complex Plasma Membrane Membrane SNARE Complex Early Endosome Membrane Protein-containing Complex
	Molecular Function	Protein Binding Dynactin Binding Type I Transforming Growth Factor Beta Receptor Binding Phosphatidylinositol Binding Protein Homodimerization Activity	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Transferrin Receptor Binding Leptin Receptor Binding
	Biological Process	Intracellular Protein Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Macroautophagy Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Retrograde Transport, Endosome To Golgi Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Histamine Secretion By Mast Cell Cellular Response To Amyloid-beta	Protein Transport Endocytic Recycling Positive Regulation Of Histamine Secretion By Mast Cell
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Celiac disease ( 23936387) Diastolic blood pressure ( 30224653) Normal facial asymmetry (angle of surface orientation score) ( 30631343)	Adult body size ( 32376654) Estimated glomerular filtration rate in non-diabetics ( 31451708) Major depressive disorder x sex interaction ( 34099189) Urate levels ( 31578528)
Interacting Genes		27 interacting genes: ACVR2B ACVRL1 BMPR1B BRCA1 BRMS1 CALM1 COIL CSNK2A2 DISC1 EGFR ESR1 INSR LEPR NDEL1 OGT OPTN PDGFRA PIM1 RAG1 SNX1 SNX2 SNX4 TEX11 TGFBR1 TGFBR2 TNIK TPT1	19 interacting genes: AGK ARL6IP1 ATP6V0A1 BIN1 DGAT2L6 EGFR HIVEP1 INSR LEPR MAGEA6 OGT PDGFRA PDGFRB PTPN5 SH3GLB1 SNX2 SNX6 SNX7 SUPT5H
Entrez ID		58533	8723
HPRD ID		12086	09334
Ensembl ID		ENSG00000129515	ENSG00000114520
Uniprot IDs		A0A0A0MRI2 Q9UNH7	O95219
PDB IDs
Enriched GO Terms of Interacting Partners?
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