KMT2C and DPY30

Number of citations of the paper that reports this interaction (PubMedID 24981860)
22

Data Source:
BioGRID (pull down, affinity chromatography technology)

		KMT2C	DPY30
Description		lysine methyltransferase 2C	dpy-30 histone methyltransferase complex regulatory subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex
	Molecular Function	DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Acyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H3-K4 Specific) Metal Ion Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Monomethylation	Endosomal Transport Histone H3-K4 Methylation
Pathways		PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS			Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)
Interacting Genes		11 interacting genes: APPL2 DPY30 H3-4 H3C1 H3C14 H4C1 JUN MAPK14 MTNR1B SMARCB1 TSC22D1	33 interacting genes: AK8 AKAP14 ARFGEF1 ASH2L BCAS4 BEND3 CDK17 CFAP91 CHMP2B CREB3L3 DYDC1 DYDC2 FAM136A GPATCH2 GTF2I H3-4 ICA1L KMT2C MRFAP1 OTX1 PRPF3 PRRC2B PSMC3 PSMD14 PXN RSPH3 SETD1A TMCC2 TSPY10 TSPY2 TSPY3 UBC ZFYVE19
Entrez ID		58508	84661
HPRD ID		06016	17434
Ensembl ID		ENSG00000055609	ENSG00000162961
Uniprot IDs		Q8NEZ4	B4DIS3 Q9C005
PDB IDs		2YSM 2YUK 3UVL 4ERY 5F59 5F6K 6KIW 6MLC	3G36 4RIQ 4RT4 4RTA 6E2H 6PWV
Enriched GO Terms of Interacting Partners?
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