NECTIN2 and USP53

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		NECTIN2	USP53
Description		nectin cell adhesion molecule 2	ubiquitin specific peptidase 53
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Cell Surface Integral Component Of Membrane Apical Junction Complex Cell-cell Contact Zone Extracellular Exosome	Cellular_component Cell-cell Junction Bicellular Tight Junction
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding	Thiol-dependent Deubiquitinase Protein Binding
	Biological Process	Acrosome Assembly Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cytoskeleton Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Spermatid Development Spermatid Nucleus Differentiation Fertilization Fusion Of Virus Membrane With Host Plasma Membrane Sperm Mitochondrion Organization Cell Part Morphogenesis Positive Regulation Of Mast Cell Activation Susceptibility To Natural Killer Cell Mediated Cytotoxicity Adhesion Of Symbiont To Host Cilium Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Viral Entry Into Host Cell Coreceptor-mediated Virion Attachment To Host Cell Positive Regulation Of T Cell Receptor Signaling Pathway Establishment Of Mitochondrion Localization Susceptibility To T Cell Mediated Cytotoxicity	Action Potential Sensory Perception Of Sound Biological_process Response To Auditory Stimulus Protein Deubiquitination Neuron Apoptotic Process
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 30498476) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Urate levels ( 31578528)	Body mass index ( 29273807) Body shape index ( 34021172) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		37 interacting genes: AFDN ATP5MF CD226 CYSRT1 DUS2 HOXA1 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP5-9 LCE1C LCE2B LCE2C LCE5A LYRM4 MAPK6 MDFI MEOX2 NBPF19 NECTIN3 NECTIN4 NOTCH2NLA NR4A3 P4HB PICK1 PVR RGS20 SIAH1 TCF4 TGM1 TIGIT USP53	9 interacting genes: CRK CRKL DAB1 GRB2 IREB2 NECTIN2 SAMD4B TRAF2 UBC
Entrez ID		5819	54532
HPRD ID		02879	11669
Ensembl ID		ENSG00000130202	ENSG00000145390
Uniprot IDs		Q92692	Q70EK8 Q9H9I0
PDB IDs		3R0N 4DFH 4DFI 4HZA 5V52
Enriched GO Terms of Interacting Partners?
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