PTPRB and MAGI3

Number of citations of the paper that reports this interaction (PubMedID 12615970)
25

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		PTPRB	MAGI3
Description		protein tyrosine phosphatase receptor type B	membrane associated guanylate kinase, WW and PDZ domain containing 3
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Specific Granule Membrane Receptor Complex Tertiary Granule Membrane	Nucleus Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction
	Molecular Function	Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Cadherin Binding	Guanylate Kinase Activity Protein Binding ATP Binding Molecular Adaptor Activity
	Biological Process	Angiogenesis Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Dephosphorylation Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity	Apoptotic Process Signal Transduction Intracellular Signal Transduction GMP Metabolic Process Regulation Of JNK Cascade GDP Metabolic Process
Pathways		Neutrophil degranulation
Drugs		{4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID (4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID {4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACID (4-ETHYLPHENYL)SULFAMIC ACID Razuprotafib
Diseases
GWAS		Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)	Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alopecia areata ( 25608926) Autoimmune thyroid disease ( 32581359) Bacteremia ( 27236921) Bulimia nervosa ( 23568457) Cerebrospinal fluid clusterin levels ( 26545630) Cognitive decline rate in late mild cognitive impairment ( 26252872) Crohn's disease ( 28067908) Gut microbiota (bacterial taxa) ( 27694959) Leukocyte telomere length ( 32109421) Lung cancer ( 31577861) Myocardial infarction ( 33532862) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Obesity-related traits ( 23251661) Parental lifespan ( 30642433) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)
Interacting Genes		12 interacting genes: CDH5 CNTN1 CNTNAP1 CTNNB1 EGFR F11R GHR MAGI3 MET NRCAM TEK TNC	18 interacting genes: ADGRB1 ADRB1 CRHR1 DSCAML1 FMR1 FZD4 FZD7 GRIN2B LATS1 NRCAM PLXNB3 PRRG4 PTEN PTPRB RPS6KA1 TGFA TNK2 VANGL2
Entrez ID		5787	260425
HPRD ID		01474	11290
Ensembl ID		ENSG00000127329	ENSG00000081026
Uniprot IDs		F8VU56 P23467 Q68D73 Q86VA4	Q5TCQ9
PDB IDs		2AHS 2H02 2H03 2H04 2HC1 2HC2 2I3R 2I3U 2I4E 2I4G 2I4H 2I5X	3SOE
Enriched GO Terms of Interacting Partners?
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