TNRC6C and AGO4

Number of citations of the paper that reports this interaction (PubMedID 19383768)
79

Data Source:
BioGRID (pull down)

		TNRC6C	AGO4
Description		trinucleotide repeat containing adaptor 6C	argonaute RISC component 4
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GO Annotations	Cellular Component	P-body Nucleoplasm Cytosol	P-body Nucleus Cytoplasm Cytosol Membrane RISC Complex Cytoplasmic Ribonucleoprotein Granule RISC-loading Complex
	Molecular Function	RNA Binding Protein Binding	Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding MiRNA Binding
	Biological Process	Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	MRNA Catabolic Process Synaptonemal Complex Assembly Male Meiotic Nuclear Division Male Gonad Development RNA Secondary Structure Unwinding MiRNA Metabolic Process Regulation Of Cell Morphogenesis Pre-miRNA Processing Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation MRNA Cleavage Involved In Gene Silencing By MiRNA MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Negative Regulation Of Apoptotic Process MRNA Cleavage Involved In Gene Silencing By SiRNA
Pathways		Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Normal facial asymmetry (angle of deformation score) ( 30631343) Refractive error ( 32231278) Serum uric acid levels ( 29559957) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		3 interacting genes: AGO4 RPTOR UBC	5 interacting genes: APP G3BP2 TNRC6A TNRC6B TNRC6C
Entrez ID		57690	192670
HPRD ID		10026	09559
Ensembl ID		ENSG00000078687	ENSG00000134698
Uniprot IDs		Q9HCJ0	Q9HCK5
PDB IDs		2DKL 2X04 3KTP	6OON
Enriched GO Terms of Interacting Partners?
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