AGO4 and TNRC6A

Number of citations of the paper that reports this interaction (PubMedID 29395067)
145

Data Source:
BioGRID (proximity labelling technology, pull down)

		AGO4	TNRC6A
Description		argonaute RISC component 4	trinucleotide repeat containing adaptor 6A
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GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane RISC Complex Cytoplasmic Ribonucleoprotein Granule RISC-loading Complex	P-body Nucleoplasm Golgi Apparatus Cytosol RISC Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding MiRNA Binding	RNA Binding Protein Binding
	Biological Process	MRNA Catabolic Process Synaptonemal Complex Assembly Male Meiotic Nuclear Division Male Gonad Development RNA Secondary Structure Unwinding MiRNA Metabolic Process Regulation Of Cell Morphogenesis Pre-miRNA Processing Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation MRNA Cleavage Involved In Gene Silencing By MiRNA MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Negative Regulation Of Apoptotic Process MRNA Cleavage Involved In Gene Silencing By SiRNA	Cellular Response To Starvation Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
Pathways		Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS			Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Experiencing mood swings ( 29500382) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Macular thickness ( 30535121) Mean platelet volume ( 32888494) Metabolic syndrome ( 31589552) Problematic alcohol use ( 32451486) Pulse pressure ( 27841878 27618448 30578418) Smoking initiation ( 33082346) Systolic blood pressure ( 27841878 27618448 30578418) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		5 interacting genes: APP G3BP2 TNRC6A TNRC6B TNRC6C	7 interacting genes: AGO4 PAN2 SMARCB1 TRIM65 TRIP13 UBC WNK1
Entrez ID		192670	27327
HPRD ID		09559	11640
Ensembl ID		ENSG00000134698	ENSG00000090905
Uniprot IDs		Q9HCK5	Q8NDV7
PDB IDs		6OON	5W6V
Enriched GO Terms of Interacting Partners?
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