SEMA6A and EVL

Number of citations of the paper that reports this interaction (PubMedID 10993894)
24

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		SEMA6A	EVL
Description		semaphorin 6A	Enah/Vasp-like
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Integral Component Of Membrane Axon	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Lamellipodium
	Molecular Function	Protein Binding Semaphorin Receptor Binding Chemorepellent Activity	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	Neural Crest Cell Migration Apoptotic Process Cytoskeleton Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Animal Organ Morphogenesis Negative Regulation Of Angiogenesis Positive Regulation Of Cell Migration Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Negative Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Negative Regulation Of Cell Adhesion Involved In Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Neuron Migration	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Nucleation Protein Homotetramerization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly
Pathways		Other semaphorin interactions	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins
Drugs
Diseases
GWAS		Allergic rhinitis ( 22036096) Amyotrophic lateral sclerosis ( 19451621) Blood protein levels ( 29875488) Body mass index ( 27296613) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Eosinophilic esophagitis ( 25017104) High chromosomal aberration frequency (chromatid type) ( 31586183) Periodontitis (DPAL) ( 24024966) Subcortical volume (MOSTest) ( 32665545) Wegener's granulomatosis ( 23740775)	Blood protein levels ( 30072576) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)
Interacting Genes		7 interacting genes: EVL ITSN2 LVRN SH3RF1 SORBS1 SORBS2 UBE2I	45 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP ATG2B BDKRB1 BEGAIN C14orf132 CKB CRKL DNMBP ENAH F11R FXR1 FXR2 FYB1 FYN GSKIP HCK HTT KRT17 KRT34 LRP1B LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 VASP WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX
Entrez ID		57556	51466
HPRD ID		06906	10942
Ensembl ID		ENSG00000092421	ENSG00000196405
Uniprot IDs		A0A0A0MQU6 Q9H2E6	A0A024R6K5 Q9UI08
PDB IDs		6WTS
Enriched GO Terms of Interacting Partners?
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