EVL and F11R

		EVL	F11R
Description		Enah/Vasp-like	F11 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Lamellipodium	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Cell Junction Cytoplasmic Vesicle Protein-containing Complex Slit Diaphragm Extracellular Exosome Tight Junction
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding	Virus Receptor Activity Integrin Binding Protein Binding PDZ Domain Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Nucleation Protein Homotetramerization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly	Regulation Of Cytokine Production Inflammatory Response Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Response To Radiation Actomyosin Structure Organization Regulation Of Actin Cytoskeleton Organization Negative Regulation Of GTPase Activity Positive Regulation Of Rho Protein Signal Transduction Maintenance Of Blood-brain Barrier Memory T Cell Extravasation Positive Regulation Of GTPase Activity Positive Regulation Of Blood Pressure Viral Entry Into Host Cell Intestinal Absorption Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Cellular Response To Mechanical Stimulus Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability Cell-cell Adhesion Positive Regulation Of Platelet Aggregation Protein Localization To Bicellular Tight Junction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Actin Cytoskeleton Reorganization Regulation Of Bicellular Tight Junction Assembly
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins	Cell surface interactions at the vascular wall Integrin cell surface interactions TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)	Inflammatory bowel disease ( 23128233) Night sleep phenotypes ( 27126917)
Interacting Genes		45 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP ATG2B BDKRB1 BEGAIN C14orf132 CKB CRKL DNMBP ENAH F11R FXR1 FXR2 FYB1 FYN GSKIP HCK HTT KRT17 KRT34 LRP1B LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 VASP WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX	31 interacting genes: AFDN ASIP BDNF CAMLG CASK CGN CSNK2A1 EVL F2RL2 ITGAL JAGN1 MARCHF2 MMP14 MPDZ MYADM PARD3 PEX19 PGAP2 PICK1 PRKCA PTPRB RABAC1 SGTA SLC30A2 SLC35A1 SNAP47 STRIT1 TJP1 TMEM100 TMEM147 TMEM86B
Entrez ID		51466	50848
HPRD ID		10942	12038
Ensembl ID		ENSG00000196405	ENSG00000158769
Uniprot IDs		A0A024R6K5 Q9UI08	Q6FIB4 Q9Y624
PDB IDs			1NBQ 3EOY 3TSZ 4ODB
Enriched GO Terms of Interacting Partners?
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