KCTD16 and GABBR2

Number of citations of the paper that reports this interaction (PubMedID 30971491)
5

Data Source:
BioGRID (pull down)

		KCTD16	GABBR2
Description		potassium channel tetramerization domain containing 16	gamma-aminobutyric acid type B receptor subunit 2
Image
GO Annotations	Cellular Component	Presynaptic Membrane Cell Projection Receptor Complex Postsynaptic Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane G Protein-coupled Receptor Heterodimeric Complex Neuron Projection Postsynaptic Membrane GABA Receptor Complex
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Homooligomerization	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Neuron-glial Cell Signaling
Pathways			Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Baclofen gamma-Aminobutyric acid SGS-742 Arbaclofen Arbaclofen Placarbil
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30940813) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Bitter alcoholic beverage consumption ( 31046077) Daytime nap ( 33568662) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Metabolite levels ( 23823483) Photic sneeze reflex ( 27182965) Refractive error ( 32231278) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261)	Gynecologic disease (multivariate analysis) ( 31488892) High chromosomal aberration frequency (chromatid type) ( 31586183) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to simvastatin treatment (PCSK9 protein level change) ( 25089948) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Schizophrenia ( 30285260) Systolic blood pressure change trajectory ( 27980656)
Interacting Genes		1 interacting genes: GABBR2	16 interacting genes: ATF4 ATF5 DRD2 GABBR1 GADD45G GLP1R HTR1A KCTD12 KCTD16 NSF RFXAP SAP30 SH3GL3 SPIN1 SPTLC1 TAMALIN
Entrez ID		57528	9568
HPRD ID		17175	09552
Ensembl ID		ENSG00000183775	ENSG00000136928
Uniprot IDs		A8K8W2 Q68DU8	H9NIL8 O75899
PDB IDs		5A15 6I0Q 6M8R 6OCP 6OCR 6OCT 6QB7	4F11 4F12 4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6M8R 6OCP 6UO8 6UO9 6UOA 6VJM 6W2X 6WIV 7C7Q 7C7S 7CA3 7CA5 7CUM
Enriched GO Terms of Interacting Partners?
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