PTH and OS9

		PTH	OS9
Description		parathyroid hormone	OS9 endoplasmic reticulum lectin
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane
	Molecular Function	Hormone Activity Protein Binding Parathyroid Hormone Receptor Binding Type 1 Parathyroid Hormone Receptor Binding Protein N-terminus Binding Receptor Ligand Activity Peptide Hormone Receptor Binding	Protease Binding Protein Binding Carbohydrate Binding
	Biological Process	Skeletal System Development Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Rho Protein Signal Transduction Cell-cell Signaling Hormone-mediated Apoptotic Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of Signal Transduction Response To Lead Ion Regulation Of Gene Expression Negative Regulation Of Gene Expression Magnesium Ion Homeostasis Positive Regulation Of Bone Mineralization Negative Regulation Of Chondrocyte Differentiation Response To Vitamin D Cellular Macromolecule Biosynthetic Process Bone Resorption Response To Ethanol Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II CAMP Metabolic Process Positive Regulation Of Glucose Import Response To Cadmium Ion Homeostasis Of Number Of Cells Within A Tissue Phosphate Ion Homeostasis Positive Regulation Of Inositol Phosphate Biosynthetic Process Response To Parathyroid Hormone Response To Fibroblast Growth Factor Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Osteoclast Proliferation Negative Regulation Of Bone Mineralization Involved In Bone Maturation	Ubiquitin-dependent Protein Catabolic Process Protein Targeting Protein Retention In ER Lumen Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Response To Endoplasmic Reticulum Stress Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC)
Drugs		D-norleucine ABX-PTH
Diseases
GWAS		Bone mineral density ( 19874204) Childhood ear infection ( 27182965) Menarche (age at onset) ( 25231870) Progression free survival in serous epithelial ovarian cancer treated with carboplatin and paclitaxel ( 28935272)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 31604244) Rheumatoid arthritis (ACPA-positive) ( 24532676)
Interacting Genes		7 interacting genes: ASPH BAG6 FEZ1 MEP1A OS9 PTH1R PTH2R	28 interacting genes: ACP1 ACVR1B CPNE6 CREB3 DCSTAMP DYSF EGLN1 EGLN3 EIF6 FAIM2 FOXM1 GLS2 HIF1A HSP90B1 LINC00839 MEP1B P3H3 PGD PTH RBX1 SCN8A SLC22A1 SMAD2 SNRPD2 SREBF2 TRPV4 UVRAG ZNF512B
Entrez ID		5741	10956
HPRD ID		01345	17804
Ensembl ID		ENSG00000152266	ENSG00000135506
Uniprot IDs		P01270	Q13438
PDB IDs		1BWX 1ET1 1ET2 1FVY 1HPH 1HPY 1HTH 1ZWA 1ZWB 1ZWD 1ZWE 1ZWF 1ZWG 2L1X 3C4M	3AIH
Enriched GO Terms of Interacting Partners?
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