RTN4 and RTN4R

Number of citations of the paper that reports this interaction (PubMedID 11201742)
318

Data Source:
HPRD (in vivo)

		RTN4	RTN4R
Description		reticulon 4	reticulon 4 receptor
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GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Postsynaptic Density Integral Component Of Endoplasmic Reticulum Membrane Cell Projection Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Membrane	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Anchored Component Of External Side Of Plasma Membrane Neuron Projection Neuronal Cell Body Dendritic Shaft Perikaryon Axonal Growth Cone Membrane Raft Extracellular Exosome Presynapse Glutamatergic Synapse
	Molecular Function	RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Cadherin Binding	Protein Binding Heparin Binding Chondroitin Sulfate Binding Signaling Receptor Activity Neuregulin Receptor Activity Protein-containing Complex Binding Ganglioside GM1 Binding Ganglioside GT1b Binding
	Biological Process	Blastocyst Formation Apoptotic Process Axonal Fasciculation Positive Regulation Of Epithelial Cell Migration Cerebral Cortex Radial Glia-guided Migration Negative Regulation Of Cell Growth Negative Regulation Of Axon Extension Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Regulation Of Apoptotic Process Protein Stabilization Nuclear Pore Complex Assembly Positive Regulation Of Protein Kinase B Signaling Cardiac Epithelial To Mesenchymal Transition Protein Localization To Lysosome Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Cellular Sphingolipid Homeostasis Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of ERBB3 Signaling Pathway Endoplasmic Reticulum Tubular Network Membrane Organization Regulation Of Branching Morphogenesis Of A Nerve	Cell Surface Receptor Signaling Pathway Axonogenesis Negative Regulation Of Neuron Projection Development Corpus Callosum Development Neuronal Signal Transduction Negative Regulation Of Axon Extension Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of Axon Regeneration
Pathways		Axonal growth inhibition (RHOA activation)	Axonal growth inhibition (RHOA activation)
Drugs
Diseases
GWAS		Adult body size ( 32376654) Fasting glucose ( 34074324) Lymphocyte counts ( 32888494) Obesity (extreme) ( 19553259) Platelet count ( 32888494) Systolic blood pressure ( 30224653 32902719)	Blood protein levels ( 30072576 29875488) Obesity-related traits ( 23251661)
Interacting Genes		55 interacting genes: BAIAP2 BCL2 BCL2L1 BDKRB1 CCR4 CERT1 CGREF1 CHMP6 CHRM4 CLN8 CNTNAP1 CRMP1 CYSLTR2 DRD2 ERBB2 ERBB3 ERBB4 F2RL1 FXR2 GLP1R GPR35 HLA-DPB1 HTR2C IPP LAMA4 LINC01554 LMNA LRCH4 LRPAP1 MBP NAPA NR4A1 NRXN1 NSD1 OGT PLEKHF2 POT1 PPP1R21 PRR13 RAB33A RPS27 RTN3 RTN4IP1 RTN4R SNX1 SNX15 SPG21 STON1 SYT16 TERF1 TUBA4A UQCRC1 UQCRC2 WWP1 ZFYVE21	13 interacting genes: HOXA1 KEAP1 LINGO1 MAG MGAT5B NEK1 NGFR OMG OTX1 PTK7 RTN4 RTN4IP1 ZDHHC8
Entrez ID		57142	65078
HPRD ID		07259	16123
Ensembl ID		ENSG00000115310	ENSG00000040608
Uniprot IDs		Q9NQC3	Q9BZR6
PDB IDs		2G31 2JV5	1OZN 1P8T
Enriched GO Terms of Interacting Partners?
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