ACKR3 and ATP13A2

Number of citations of the paper that reports this interaction (PubMedID 22645275)
28

Data Source:
BioGRID (two hybrid)

		ACKR3	ATP13A2
Description		atypical chemokine receptor 3	ATPase cation transporting 13A2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endosome Early Endosome Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome	Autophagosome Membrane Lysosome Lysosomal Membrane Late Endosome Multivesicular Body Autophagosome Integral Component Of Membrane Transport Vesicle Late Endosome Membrane Vesicle Multivesicular Body Membrane Neuron Projection Neuronal Cell Body Lysosomal Lumen Integral Component Of Lysosomal Membrane
	Molecular Function	Scavenger Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding C-X-C Chemokine Binding	Protein Binding ATP Binding Zinc Ion Binding ABC-type Polyamine Transporter Activity ATP Hydrolysis Activity ATPase-coupled Cation Transmembrane Transporter Activity Manganese Ion Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding Cupric Ion Binding
	Biological Process	Angiogenesis Vasculogenesis Immune Response Cell Adhesion G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Cell Population Proliferation Calcium-mediated Signaling Receptor Internalization Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Mesenchymal Stem Cell Migration	Cellular Calcium Ion Homeostasis Cellular Iron Ion Homeostasis Cellular Zinc Ion Homeostasis Autophagy Lysosomal Transport Positive Regulation Of Gene Expression Regulation Of Mitochondrion Organization Regulation Of Macroautophagy Regulation Of Autophagosome Size Cellular Cation Homeostasis Regulation Of Intracellular Protein Transport Ion Transmembrane Transport Cellular Response To Oxidative Stress Protein Autophosphorylation Positive Regulation Of Protein Secretion Regulation Of Endopeptidase Activity Zinc Ion Homeostasis Lipid Homeostasis Protein Localization To Lysosome Autophagosome-lysosome Fusion Cellular Response To Manganese Ion Cellular Response To Zinc Ion Extracellular Exosome Biogenesis Regulation Of Protein Localization To Nucleus Negative Regulation Of Neuron Death Polyamine Transmembrane Transport Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Exosomal Secretion Spermine Transmembrane Transport Regulation Of Chaperone-mediated Autophagy Autophagosome Organization Regulation Of Glucosylceramidase Activity Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Lysosomal Protein Catabolic Process Peptidyl-aspartic Acid Autophosphorylation Regulation Of Ubiquitin-specific Protease Activity
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Ion transport by P-type ATPases
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Disease progression in age-related macular degeneration ( 29346644) Heel bone mineral density ( 30598549) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 25429064 31562340 20189936) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 28552196 34021172 25673412) Intraocular pressure ( 29617998) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196 34021172) Waist-hip index ( 34021172)
Interacting Genes		2 interacting genes: ATP13A2 TP53	36 interacting genes: ACKR3 ATP5MC2 CCKBR CMTM6 COL1A1 CXCR4 CYGB DCAF7 EMC7 F2R FAM111B FAM8A1 FKBP8 FUNDC2 GPR21 HIPK1 ICAM2 LMAN2 LRP6 MEX3B MYCBP2 NPY1R NRXN1 OCA2 OSTC PCDHB10 PCMTD2 PDIA6 PSME3IP1 SEC61B SPCS2 TSPAN14 UBE2J2 VAMP2 WDR5B WDR83OS
Entrez ID		57007	23400
HPRD ID		09882	13677
Ensembl ID		ENSG00000144476	ENSG00000159363
Uniprot IDs		P25106	Q8N4D4 Q8NBS1 Q9NQ11
PDB IDs		6K3F
Enriched GO Terms of Interacting Partners?
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