PMEPA1 and DCTN6

Number of citations of the paper that reports this interaction (PubMedID 28218281)
1

Data Source:
BioGRID (pull down)

		PMEPA1	DCTN6
Description		prostate transmembrane protein, androgen induced 1	dynactin subunit 6
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Plasma Membrane Endosome Membrane Integral Component Of Membrane Early Endosome Membrane Intracellular Membrane-bounded Organelle	Kinetochore Centrosome Cytosol Dynactin Complex
	Molecular Function	Protein Binding WW Domain Binding R-SMAD Binding	Dynein Complex Binding
	Biological Process	Negative Regulation Of SMAD Protein Complex Assembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Androgen Receptor Signaling Pathway Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Mitotic Spindle Organization
Pathways		Downregulation of TGF-beta receptor signaling	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Response to fenofibrate (adiponectin levels) ( 23149075) Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster) ( 33455090) Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster)(time to event) ( 33455090) Serum alkaline phosphatase levels ( 33547301)	Breast size ( 27182965) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		11 interacting genes: DCTN5 DCTN6 EPN2 HGS NEDD4 OTUB2 SGTA STAM UBASH3A UBQLN2 UBQLN4	9 interacting genes: APP CDK1 ERRFI1 HSPB2 IDO1 NCOA3 PMEPA1 RPSA UBXN8
Entrez ID		56937	10671
HPRD ID		09415	09907
Ensembl ID		ENSG00000124225	ENSG00000104671
Uniprot IDs		Q5JY37 Q969W9	O00399
PDB IDs			3TV0
Enriched GO Terms of Interacting Partners?
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