SMCO4 and PLD3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SMCO4	PLD3
Description		single-pass membrane protein with coiled-coil domains 4	phospholipase D family member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Integral Component Of Membrane	Golgi Membrane Lysosomal Membrane Endoplasmic Reticulum Membrane Integral Component Of Membrane Early Endosome Membrane Late Endosome Membrane Lysosomal Lumen Extracellular Exosome
	Molecular Function	Molecular_function Protein Binding	Phospholipase D Activity Protein Binding Single-stranded DNA 5'-3' Exodeoxyribonuclease Activity
	Biological Process	Biological_process	Immune System Process DNA Metabolic Process Inflammatory Response Myotube Differentiation Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways			Synthesis of PG Role of phospholipids in phagocytosis
Drugs
Diseases
GWAS		Adult body size ( 32376654) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Liver enzyme levels (alanine transaminase) ( 33972514)	Otitis media ( 27632927) Otitis media (chronic) ( 27632927) Otitis media (recurrent) ( 27632927)
Interacting Genes		60 interacting genes: AQP6 ATP2A2 BNIP3L CD79A CLEC10A CLTRN CPLX4 CREB3L1 CXCR2 EBP ERGIC3 FAM174A FAM209A FAM210B FFAR2 GJA8 GKN1 GPA33 GPR152 GPR42 HHLA2 ICAM3 IL10RA KASH5 KCNK5 KIR3DL1 KRT40 KRTAP10-3 KRTAP10-7 LEPROTL1 LMNA LRRC25 M6PR MGST3 MS4A3 MUC1 PEX12 PLD3 PTGES RETREG3 SCN3B SLC16A2 SLC18A1 SLC35C2 SLC41A3 SLC7A1 SLC7A14 SMIM3 SPINT1 STOM SUSD3 SYNE4 SYNPR TEX29 TFEC TMEM139 TMEM80 TMX2 VSIR WBP1	16 interacting genes: ANXA7 ATG16L1 BCL2L1 CIC CNIH3 GPR35 HGS NFKB1 OGT OPRM1 SMCO4 SOX4 SPP1 STK11 TK1 VRK2
Entrez ID		56935	23646
HPRD ID		17008	07148
Ensembl ID		ENSG00000166002	ENSG00000105223
Uniprot IDs		A0A024R3A3 Q9NRQ5	A0A024R0Q4 Q8IV08
PDB IDs
Enriched GO Terms of Interacting Partners?
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