C1GALT1 and GJB5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		C1GALT1	GJB5
Description		core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	gap junction protein beta 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane	Connexin Complex Integral Component Of Membrane
	Molecular Function	Protein Binding Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity Metal Ion Binding	Gap Junction Channel Activity Protein Binding
	Biological Process	Angiogenesis Kidney Development O-glycan Processing, Core 1 Cell Differentiation	Cell-cell Signaling Epidermis Development Transmembrane Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Morphogenesis Epididymis Development
Pathways		Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) O-linked glycosylation of mucins	Gap junction assembly
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 29875488) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 30224653) Erosive tooth wear (severe vs non-severe) ( 29898447) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 28166213 30804560) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis (severity) ( 19010793) Night sleep phenotypes ( 27126917) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Serum galactose-deficient IgA1 levels ( 28187132) Serum galactose-deficient IgA1 levels in IgA nephropathy ( 33593824) Smooth-surface caries ( 24556642) Systolic blood pressure ( 26969751) Visceral adipose tissue adjusted for BMI ( 22589738)	BMI x environmental factors (excluding physical activity) interaction ( 33654129) BMI x environmental factors (including physical activity) interaction ( 33654129) Narcolepsy ( 23459209) Sleep duration (short sleep) ( 30846698) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		32 interacting genes: ANKS6 ARL13B C1GALT1C1 CD79A CPLX4 ELOVL4 FAM209A FAM210B GJA8 GJB1 GJB5 GPR101 GPR151 GPR42 GPRC5D GPX8 GSDME LEPROT LEUTX LHFPL5 MUC1 PIGP RETREG3 SLC14A1 SLC1A1 SLC7A14 STX1A TMEM14B TMEM237 TMEM52B TRAF6 XRN1	45 interacting genes: APOL2 APOL3 AQP1 C1GALT1 C4orf3 COMT CTXN3 CYB5B DNALI1 ERG28 FAM3C GSK3B IGFBP5 JAGN1 LMNA LPAR3 LRP10 MED1 MIP MS4A13 MYL2 NAPB PCGF2 PGAP2 PLPP4 PLPP6 PNLIPRP1 RPRM RTP2 SEC22A SEC22B SERP1 SLC30A2 SLC38A7 SLC41A1 SLC41A2 SMIM1 TM4SF4 TMEM128 TMEM60 TMEM86A TMEM97 TRIM2 TSPO2 VSTM1
Entrez ID		56913	2709
HPRD ID		16631	06840
Ensembl ID		ENSG00000106392	ENSG00000189280
Uniprot IDs		A0A024RA32 Q9NS00	A0A654IE64 O95377
PDB IDs
Enriched GO Terms of Interacting Partners?
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