MAP2K2 and CNKSR1

Number of citations of the paper that reports this interaction (PubMedID 9427625)
47

Data Source:
HPRD (two hybrid)

		MAP2K2	CNKSR1
Description		mitogen-activated protein kinase kinase 2	connector enhancer of kinase suppressor of Ras 1
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Mitochondrion Early Endosome Late Endosome Peroxisomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule Cell-cell Junction Focal Adhesion Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane Cell-cell Junction Cell Cortex
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding PDZ Domain Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	MAPK Cascade Peptidyl-tyrosine Phosphorylation Regulation Of Stress-activated MAPK Cascade Peptidyl-serine Autophosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription, DNA-templated ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Inheritance Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of Early Endosome To Late Endosome Transport	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction
Pathways		MAPK1 (ERK2) activation Frs2-mediated activation Signal transduction by L1 Uptake and function of anthrax toxins RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by RAF1 mutants	MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		Bosutinib Trametinib Selumetinib Binimetinib Fostamatinib
Diseases
GWAS		Eosinophil counts ( 32888494) Heel bone mineral density ( 30598549) Height ( 29782485) Lymphocyte counts ( 32888494) Pulse pressure ( 30224653) White blood cell count ( 32888494)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		20 interacting genes: ARAF BRAF CASP9 CCNDBP1 CNKSR1 COPS5 DUSP3 GRIN1 GRIN2D HNRNPK LAMTOR3 LIG4 MAPK1 MAPK3 MAPK8 MOS RAF1 RGS12 RIPOR2 ZNF207	23 interacting genes: ARHGEF1 BRAP CADM4 CYTH1 CYTH2 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT
Entrez ID		5605	10256
HPRD ID		03164	11937
Ensembl ID		ENSG00000126934	ENSG00000142675
Uniprot IDs		P36507	B4DL25 G3V160 Q53GM7 Q969H4
PDB IDs		1S9I 4H3Q	1WWV
Enriched GO Terms of Interacting Partners?
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