MAPK13 and GPX4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		MAPK13	GPX4
Description		mitogen-activated protein kinase 13	glutathione peroxidase 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nuclear Envelope Mitochondrion Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Selenium Binding Identical Protein Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity
	Biological Process	Response To Osmotic Stress Cell Cycle Peptidyl-serine Phosphorylation Positive Regulation Of Interleukin-6 Production Cellular Response To UV Intracellular Signal Transduction Positive Regulation Of Inflammatory Response Stress-activated MAPK Cascade Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Sorbitol Cellular Response To Anisomycin Cellular Response To Sodium Arsenite	Chromatin Organization Phospholipid Metabolic Process Glutathione Metabolic Process Response To Oxidative Stress Spermatogenesis Aging Arachidonic Acid Metabolic Process Lipoxygenase Pathway Response To Estradiol Long-chain Fatty Acid Biosynthetic Process Regulation Of Inflammatory Response Protein Polymerization Cellular Oxidant Detoxification Negative Regulation Of Ferroptosis
Pathways		NOD1/2 Signaling Pathway p38MAPK events DSCAM interactions VEGFA-VEGFR2 Pathway	Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives
Drugs		Minocycline KC706 Fostamatinib	Glutathione Glutathione Glutathione disulfide
Diseases
GWAS		Birth weight ( 31043758) Blood protein levels ( 30072576 29875488) Offspring birth weight ( 31043758)	Advanced age-related macular degeneration ( 26691988) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 31174203) Crohn's disease ( 28067908 21102463 23128233) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) hemolysis of donated blood (oxidative) ( 34014839) Inflammatory bowel disease ( 28067908) Keratinocyte cancer (MTAG) ( 31174203) Liver enzyme levels (alkaline phosphatase) ( 33972514) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		16 interacting genes: AKIP1 ANKLE2 APP ATF2 EEF2K FGF12 GPX4 HTRA2 MAP2K6 MAP3K4 MAPKAPK3 MAPKAPK5 MAPT MBP SMAD4 SQSTM1	10 interacting genes: APBA3 EGR4 FUT5 GAMT GTF2F1 MAPK13 MATK PARK7 PRDX6 ZNF197
Entrez ID		5603	2879
HPRD ID		09113	11819
Ensembl ID		ENSG00000156711	ENSG00000167468
Uniprot IDs		A0A024RD04 O15264	P36969 Q6PI42
PDB IDs		3COI 4EYJ 4EYM 4MYG 4YNO 5EKN 5EKO	2GS3 2OBI 5H5Q 5H5R 5H5S 6ELW 6HKQ 6HN3
Enriched GO Terms of Interacting Partners?
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