GPX4 and APBA3

		GPX4	APBA3
Description		glutathione peroxidase 4	amyloid beta precursor protein binding family A member 3
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Mitochondrion Cytosol Protein-containing Complex Extracellular Exosome	Cytoplasm Plasma Membrane Dendritic Spine Perinuclear Region Of Cytoplasm
	Molecular Function	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Selenium Binding Identical Protein Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity	Amyloid-beta Binding Enzyme Inhibitor Activity Protein Binding Enzyme Binding
	Biological Process	Chromatin Organization Phospholipid Metabolic Process Glutathione Metabolic Process Response To Oxidative Stress Spermatogenesis Aging Arachidonic Acid Metabolic Process Lipoxygenase Pathway Response To Estradiol Long-chain Fatty Acid Biosynthetic Process Regulation Of Inflammatory Response Protein Polymerization Cellular Oxidant Detoxification Negative Regulation Of Ferroptosis	In Utero Embryonic Development Chemical Synaptic Transmission Regulation Of Gene Expression Protein Transport Negative Regulation Of Catalytic Activity
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives	Neurexins and neuroligins
Drugs		Glutathione Glutathione Glutathione disulfide
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 31174203) Crohn's disease ( 28067908 21102463 23128233) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) hemolysis of donated blood (oxidative) ( 34014839) Inflammatory bowel disease ( 28067908) Keratinocyte cancer (MTAG) ( 31174203) Liver enzyme levels (alkaline phosphatase) ( 33972514) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494)	Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		10 interacting genes: APBA3 EGR4 FUT5 GAMT GTF2F1 MAPK13 MATK PARK7 PRDX6 ZNF197	10 interacting genes: APP ARF3 ARF4 AZI2 BCR BDNF EGFR GPX4 TANK TBKBP1
Entrez ID		2879	9546
HPRD ID		11819	05038
Ensembl ID		ENSG00000167468	ENSG00000011132
Uniprot IDs		P36969 Q6PI42	O96018
PDB IDs		2GS3 2OBI 5H5Q 5H5R 5H5S 6ELW 6HKQ 6HN3	2YT7 2YT8 5UWS
Enriched GO Terms of Interacting Partners?
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