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ERBIN and LRRC1
Number of citations of the paper that reports this interaction (PubMedID
11440998
)
15
Data Source:
BioGRID
(pull down)
HPRD
(in vivo, in vitro, two hybrid)
ERBIN
LRRC1
Description
erbb2 interacting protein
leucine rich repeat containing 1
Image
No pdb structure
GO Annotations
Cellular Component
Basement Membrane
Nucleus
Cytoplasm
Plasma Membrane
Basal Plasma Membrane
Basolateral Plasma Membrane
Nuclear Speck
Cell Junction
Hemidesmosome
Nuclear Membrane
Postsynapse
Glutamatergic Synapse
Cytosol
Membrane
Molecular Function
Signaling Receptor Binding
ErbB-2 Class Receptor Binding
Structural Constituent Of Cytoskeleton
Protein Binding
Biological Process
Protein Targeting
Cell Adhesion
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Muramyl Dipeptide
Response To Lipopolysaccharide
Intermediate Filament Cytoskeleton Organization
Basal Protein Localization
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Positive Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Monocyte Chemotactic Protein-1 Production
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways
Signaling by ERBB2
Downregulation of ERBB2 signaling
RHOA GTPase cycle
RHOB GTPase cycle
RHOC GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOG GTPase cycle
RAC3 GTPase cycle
Constitutive Signaling by Overexpressed ERBB2
Drug-mediated inhibition of ERBB2 signaling
Signaling by ERBB2 KD Mutants
Resistance of ERBB2 KD mutants to trastuzumab
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to lapatinib
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drug resistance in ERBB2 TMD/JMD mutants
RND2 GTPase cycle
Drugs
Diseases
GWAS
Heel bone mineral density (
30598549
)
Hip index (
34021172
)
Metabolite levels (
23823483
)
Motor coordination (
34177493
)
Interacting Genes
68 interacting genes:
ABCA1
ABCC4
ABR
ACTN1
ACTN2
ACVR2A
ACVR2B
AGTR2
APC
ARHGEF7
ARVCF
ATP2B1
ATP2B2
ATP2B4
BANF1
CASK
CDH1
CHUK
COPB1
CTNNB1
CTNND1
CTNND2
CTSG
CWC27
DLG4
DST
ERBB2
FOXO3
GRIN2B
GRIN2C
GUCY1A2
ITGB4
KCNA4
KCNA5
KEAP1
LAMB1
LMO1
LMO2
LRRC1
MAP4
MAPK12
MCC
MEF2A
MPP1
MPP2
MPP3
MUSK
NOD2
NR2E1
PICK1
PKP4
RAF1
RBX1
RNF7
RPS6KA1
SCN4A
SHOC2
SLC5A5
SLC5A6
SLC6A12
SMAD1
SMAD2
SMAD3
SMAD4
SMAD7
STAT3
VIPR2
ZFYVE9
6 interacting genes:
APP
CEP126
CRMP1
DLG1
DLG4
ERBIN
Entrez ID
55914
55227
HPRD ID
06090
06430
Ensembl ID
ENSG00000112851
ENSG00000137269
Uniprot IDs
Q96RT1
Q9BTT6
PDB IDs
1MFG
1MFL
1N7T
2H3L
2QBW
3CH8
6Q0M
6Q0N
6Q0U
6UBG
6UBH
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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