ERBIN and ATP2B1

Number of citations of the paper that reports this interaction (PubMedID 15123239)
21

Data Source:
BioGRID (unspecified method)

		ERBIN	ATP2B1
Description		erbb2 interacting protein	ATPase plasma membrane Ca2+ transporting 1
Image
GO Annotations	Cellular Component	Basement Membrane Nucleus Cytoplasm Plasma Membrane Basal Plasma Membrane Basolateral Plasma Membrane Nuclear Speck Cell Junction Hemidesmosome Nuclear Membrane Postsynapse Glutamatergic Synapse	Immunological Synapse Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Integral Component Of Synaptic Vesicle Membrane Dendritic Spine Membrane Neuronal Cell Body Membrane Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Exosome Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Presynaptic Active Zone Membrane
	Molecular Function	Signaling Receptor Binding ErbB-2 Class Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding	P-type Calcium Transporter Activity Protein Binding Calmodulin Binding ATP Binding Calcium Ion Transmembrane Transporter Activity ATP Hydrolysis Activity ATPase-coupled Cation Transmembrane Transporter Activity PDZ Domain Binding Metal Ion Binding P-type Calcium Transporter Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration
	Biological Process	Protein Targeting Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Muramyl Dipeptide Response To Lipopolysaccharide Intermediate Filament Cytoskeleton Organization Basal Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Ras Protein Signal Transduction Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Tumor Necrosis Factor Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Negative Regulation Of Cytokine Production Regulation Of Vascular Associated Smooth Muscle Contraction Neural Retina Development Cellular Calcium Ion Homeostasis Brain Development Aging Regulation Of Blood Pressure Response To Cold Positive Regulation Of Bone Mineralization Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transport Cellular Response To Vitamin D Cellular Response To Corticosterone Stimulus Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Cellular Response To Insulin Stimulus Regulation Of Cardiac Conduction Calcium Ion Export Across Plasma Membrane
Pathways		Signaling by ERBB2 Downregulation of ERBB2 signaling RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants	Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases Sensory processing of sound by inner hair cells of the cochlea
Drugs			Halothane Desflurane
Diseases
GWAS			Adult body size ( 32376654) Automobile speeding propensity ( 30643258) Biomedical quantitative traits ( 19396169) Blood pressure ( 24954895 21572416 24001895 21909110) Calcium levels ( 29403010) Chronotype ( 30696823) Coronary artery disease ( 32469254 29212778 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 22751097) Diastolic blood pressure ( 26390057 19430479 27841878 29403010 28739976 27618452 25249183 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure (long-term average) ( 28348047) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Diffusing capacity of carbon monoxide ( 30694715) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypertension ( 31513605 31879980 19430479 32709000 25249183 28273873 30487518) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Magnesium levels ( 20700443) Mean arterial pressure ( 26390057 29403010 27618448 30487518) Mean arterial pressure (long-term average) ( 28348047) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Morning person ( 30696823) Myocardial infarction ( 33532862 26343387) Nonobstructive coronary artery disease ( 26534935) Pulse pressure ( 26390057 27841878 29403010 28739976 30487518 30578418) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 30224653 26390057 19430479 27841878 29403010 28739976 27618447 27618452 25249183 30487518 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure (long-term average) ( 28348047) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Total body bone mineral density ( 29304378)
Interacting Genes		68 interacting genes: ABCA1 ABCC4 ABR ACTN1 ACTN2 ACVR2A ACVR2B AGTR2 APC ARHGEF7 ARVCF ATP2B1 ATP2B2 ATP2B4 BANF1 CASK CDH1 CHUK COPB1 CTNNB1 CTNND1 CTNND2 CTSG CWC27 DLG4 DST ERBB2 FOXO3 GRIN2B GRIN2C GUCY1A2 ITGB4 KCNA4 KCNA5 KEAP1 LAMB1 LMO1 LMO2 LRRC1 MAP4 MAPK12 MCC MEF2A MPP1 MPP2 MPP3 MUSK NOD2 NR2E1 PICK1 PKP4 RAF1 RBX1 RNF7 RPS6KA1 SCN4A SHOC2 SLC5A5 SLC5A6 SLC6A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STAT3 VIPR2 ZFYVE9	9 interacting genes: CALM1 CCR2 CSNK2A1 DAO ERBIN F2RL1 PRKACA PRKCA TRIM32
Entrez ID		55914	490
HPRD ID		06090	00158
Ensembl ID		ENSG00000112851	ENSG00000070961
Uniprot IDs		Q96RT1	A0A024RBC7 P20020
PDB IDs		1MFG 1MFL 1N7T 2H3L 2QBW 3CH8 6Q0M 6Q0N 6Q0U 6UBG 6UBH	6A69
Enriched GO Terms of Interacting Partners?
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