KMT2E and ATP13A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KMT2E	ATP13A1
Description		lysine methyltransferase 2E (inactive)	ATPase 13A1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Plasma Membrane Nuclear Body Nuclear Speck Protein-containing Complex Transcriptionally Active Chromatin	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Histone-lysine N-methyltransferase Activity Enzyme Binding Methylated Histone Binding Metal Ion Binding	ATP Binding ABC-type Manganese Transporter Activity ATP Hydrolysis Activity Metal Ion Binding Transmembrane Protein Dislocase Activity
	Biological Process	Neutrophil Mediated Immunity DNA Methylation Chromatin Organization Cell Cycle Erythrocyte Differentiation Neutrophil Activation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Histone H3-K4 Trimethylation	Cellular Calcium Ion Homeostasis Protein Transport Ion Transmembrane Transport Manganese Ion Transmembrane Transport Extraction Of Mislocalized Protein From ER Membrane
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Ion transport by P-type ATPases
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Autism spectrum disorder ( 30804558) Autism spectrum disorder or schizophrenia ( 28540026) General risk tolerance (MTAG) ( 30643258) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Schizophrenia ( 29483656)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Serum alkaline phosphatase levels ( 33339817) Toenail selenium levels ( 25343990) White blood cell count ( 32888494)
Interacting Genes		12 interacting genes: ALKBH4 ASH2L ATP13A1 CDK1 CYP2C18 FIS1 IFT22 LAMTOR5 MAPRE2 NFE4 TRAPPC14 ZCWPW1	31 interacting genes: AGTR1 APPBP2 AQP6 ARHGEF5 BUD31 CBARP CXCR2 EBP ELOVL4 FAM209A FFAR2 GLP1R GPR42 KMT2E MANBAL MFSD14B MMD RNASEK SCN3B SLC10A6 SLC16A13 SLC30A2 SLC30A8 SLC35C2 SYPL2 TLCD4 TMBIM6 TMEM14B TMEM237 UNC93A VMA21
Entrez ID		55904	57130
HPRD ID		10528	12501
Ensembl ID		ENSG00000005483	ENSG00000105726
Uniprot IDs		Q8IZD2	A0A024R7N2 Q9HD20
PDB IDs		2LV9 4L58 5HT6
Enriched GO Terms of Interacting Partners?
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