VAC14 and HNF1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		VAC14	HNF1B
Description		VAC14 component of PIKFYVE complex	HNF1 homeobox B
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extrinsic Component Of Vacuolar Membrane Endoplasmic Reticulum Cytosol Endosome Membrane Early Endosome Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle PAS Complex	Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Signaling Receptor Activity Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Signal Transduction Positive Regulation Of Kinase Activity	Kidney Development Regulation Of Transcription By RNA Polymerase II Response To Xenobiotic Stimulus Response To Carbohydrate Response To Organic Cyclic Compound Insulin Secretion Pancreas Development Circadian Regulation Of Gene Expression Regulation Of Pronephros Size Pronephric Nephron Tubule Development Positive Regulation Of Transcription, DNA-templated Embryonic Morphogenesis Pronephros Development Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Protein-DNA Complex Assembly Hepatocyte Differentiation
Pathways		Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Regulation of gene expression in early pancreatic precursor cells
Drugs
Diseases
GWAS		Diffuse cutaneous systemic sclerosis ( 29293537) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) High density lipoprotein cholesterol levels ( 28548082) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061) Pulse pressure ( 28135244)	Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood urea nitrogen levels ( 31152163 29403010) Body mass index ( 28892062) C-reactive protein levels ( 33339817) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Endometrial cancer ( 30093612 27008869 21499250 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Epithelial ovarian cancer ( 25581431) Frontotemporal dementia ( 26154020) Gallstone disease ( 30504769) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Medication use (drugs used in diabetes) ( 31015401) Neuritic plaque ( 25188341) Ovarian cancer ( 23535730) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Prostate cancer ( 20676098 18264096 18264097 30410027 31562322 25939597 34012061 26443449 27262462) Prostate-specific antigen levels ( 30410027 28139693) Serum prostate-specific antigen levels ( 21160077) Testicular germ cell tumor ( 25877299 28604728 28604732) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 23945395 22961080 32499647 20581827 30718926 28869590)
Interacting Genes		108 interacting genes: ABHD11 ACSS1 AMT APP ARID5A ASB13 BCL2L1 BHLHE40 C11orf54 C19orf54 C2CD6 C4orf33 CASP1 CCDC103 CD209 CDRT4 CNTN2 COL8A1 CRK CRYBA1 CRYBA2 DDAH2 EEF1AKMT3 EHHADH EIF2S1 EIF6 FAM50B FIG4 FNDC3B GABPB2 GALT GINS3 GLIS2 GNB1 GTF3C2 HDHD3 HNF1B HNRNPLL INTS11 JMJD7 KEAP1 KHDC1 KRBOX5 KRT82 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LINC00518 LPAL2 MBLAC1 MEOX2 METTL15 MGAT5B MPPED2 MTMR9 MVP MYOZ1 NDUFAB1 NGB NOS1 NTAQ1 OIT3 OTOS PBLD PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PPP6C PRADC1 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX2 RHBDL1 RHOXF2 RIPPLY1 RNASEH2C RSKR SIGLEC5 SMUG1 SNF8 SPRYD7 SRPK2 TCEANC TEX37 TP53BP1 TRIM55 TRIM63 UFSP1 VENTX VHLL WDR83 WRAP53 ZBTB49 ZCWPW1 ZNF34	22 interacting genes: ALDOC ASGR2 ATF1 BPIFA1 C10orf55 CDK5R1 CREB1 CREBBP CRX ERC2 H3C1 HNF1A KRTAP26-1 MLLT10 OTX2 OXER1 PARD3 PCBD1 POU6F2 UFSP1 USP54 VAC14
Entrez ID		55697	6928
HPRD ID		07660	08926
Ensembl ID		ENSG00000103043	ENSG00000275410
Uniprot IDs		Q08AM6	A0A087WZC2 A0A0C4DGS8 E0YMJ6 P35680 Q6FHW6
PDB IDs			2DA6 2H8R 5K9S
Enriched GO Terms of Interacting Partners?
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