CSGALNACT2 and FCGR2A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CSGALNACT2	FCGR2A
Description		chondroitin sulfate N-acetylgalactosaminyltransferase 2	Fc fragment of IgG receptor IIa
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Membrane Integral Component Of Golgi Membrane Golgi Cisterna Membrane	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Secretory Granule Membrane
	Molecular Function	Protein Binding Acetylgalactosaminyltransferase Activity Metal Ion Binding Glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity	Transmembrane Signaling Receptor Activity Protein Binding IgG Binding
	Biological Process	Proteoglycan Biosynthetic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process	Immune System Process Cell Surface Receptor Signaling Pathway Regulation Of Immune Response
Pathways		Chondroitin sulfate biosynthesis	FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Neutrophil degranulation FCGR3A-mediated IL10 synthesis
Drugs			Cetuximab Etanercept Human immunoglobulin G Abciximab Alemtuzumab Daclizumab Bevacizumab Catumaxomab Sarilumab
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Central corneal thickness ( 32528159) Hip circumference adjusted for BMI ( 34021172) Hirschsprung disease ( 25310821) Multiple sclerosis ( 24076602)	Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576 29875488 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Hematocrit ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908 23128233) Kawasaki disease ( 28886140 33772158 22081228) Lipid metabolism phenotypes ( 22286219) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 24871463 26663301 26502338 28714469) Takayasu arteritis ( 23830517) Ulcerative colitis ( 19915573 28067908 20228799 21297633)
Interacting Genes		20 interacting genes: ARL13B ATP1B4 BSND CLDN2 CREB3L1 CYB5R3 FCGR2A GPR152 HSD17B11 LMNA MFSD14B MUC1 RETREG3 SLC35E3 SSMEM1 SYNE4 SYT1 TMEM143 TMEM52B UBE2I	37 interacting genes: ACTR2 ADAM33 AGPAT4 BLK CDIPT CMTM5 CRP CRYAB CSGALNACT2 CXCL9 F5 FAM3B FCER1A FCER1G FCGR2B FCGR3A FXYD3 FYN GIMAP1 GP6 GRB2 HCK LAT LGALS3 LIMK2 LYN MGST3 MIP NSG1 PIK3R1 SERP2 SHC1 SYK TARDBP TMCO1 UBQLN1 UPK2
Entrez ID		55454	2212
HPRD ID		11348	00906
Ensembl ID		ENSG00000169826	ENSG00000143226
Uniprot IDs		A0A0S2Z5F5 A0A0S2Z5F9 A0A0S2Z5K4 Q8N6G5	P12318
PDB IDs			1FCG 1H9V 3D5O 3RY4 3RY5 3RY6
Enriched GO Terms of Interacting Partners?
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