LGR4 and RSPO3

  • Number of citations of the paper that reports this interaction (PubMedID 29752411)
  • 20
  • Data Source:
  • BioGRID (pull down, pull down, fluorescent resonance energy transfer)

LGR4

RSPO3

Description leucine rich repeat containing G protein-coupled receptor 4 R-spondin 3
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Blond vs. brown/black hair color ( 30531825)
  • Bone mineral density ( 23644456)
  • Bone mineral density (paediatric, skull) ( 24945404)
  • Brain morphology (MOSTest) ( 32665545)
  • Dental caries (decayed, missing and filled teeth) ( 31533690)
  • Heel bone mineral density ( 30598549)
  • Male-pattern baldness ( 28196072)
  • Menarche (age at onset) ( 25231870)
  • Spontaneous preterm birth with premature rupture of membranes ( 31194736)
  • Survival in pancreatic cancer ( 28470677)
  • Urate levels in obese individuals ( 25811787)
  • Alanine aminotransferase levels ( 34315874)
  • Apolipoprotein A1 levels ( 32203549)
  • Apolipoprotein B levels ( 32203549)
  • Aspartate aminotransferase levels ( 33547301 34315874)
  • Blood pressure ( 23972371)
  • Blood protein levels ( 30072576 29875488)
  • Blood urea nitrogen levels ( 31152163 29403010)
  • Body shape index ( 34021172)
  • Bone mineral density ( 21533022)
  • Bone mineral density (paediatric, skull) ( 24945404)
  • Bone mineral density (paediatric, total body less head) ( 24945404)
  • Bone mineral density (paediatric, upper limb) ( 24945404)
  • Bone mineral density (spine) ( 26733130)
  • Bone properties (heel) ( 24430505)
  • Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463)
  • Bone ultrasound measurement (velocity of sound) ( 28472463)
  • C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809)
  • Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216)
  • Cortical surface area ( 32963231)
  • Cortical volume ( 32963231)
  • Crohn's disease ( 28067908)
  • Diastolic blood pressure ( 27841878 29403010 28739976 27618452 30487518)
  • Diastolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
  • Fasting insulin ( 33402679 34059833)
  • Femoral neck bone mineral density ( 29499414 22504420)
  • Food addiction ( 27106561)
  • Fractures ( 30158200 30598549)
  • HDL cholesterol ( 24097068 30275531)
  • HDL cholesterol levels ( 32203549 28334899 30698716)
  • HDL cholesterol levels in current drinkers ( 30698716)
  • HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535)
  • HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
  • Heel bone mineral density ( 30598549 30048462 28869591)
  • Hematocrit ( 32888494)
  • Hemoglobin ( 32888494)
  • Hemoglobin concentration ( 27863252)
  • Hemoglobin levels ( 32327693)
  • High density lipoprotein cholesterol levels ( 33339817)
  • Hip circumference ( 31453325)
  • Hip circumference adjusted for BMI ( 34021172 25673412)
  • Hip circumference variance ( 31453325)
  • Hip index ( 34021172)
  • Intracranial volume ( 22504418)
  • Iron status biomarkers ( 19084217)
  • LDL cholesterol levels ( 32203549)
  • LDL cholesterol levels in HIV infection ( 33109212)
  • Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
  • Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025)
  • Liver volume ( 34128465)
  • Low density lipoprotein cholesterol levels ( 32154731)
  • Lung function (FVC) ( 30061609)
  • Lymphocyte counts ( 32888494)
  • Lymphocyte percentage of white cells ( 32888494)
  • Male-pattern baldness ( 27182965)
  • Mean arterial pressure ( 29403010 30487518)
  • Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Medication use (HMG CoA reductase inhibitors) ( 31015401)
  • Menarche (age at onset) ( 27182965)
  • Metabolic syndrome ( 31589552)
  • Metabolite levels ( 21909109)
  • Monobrow ( 27182965)
  • Neutrophil percentage of white cells ( 32888494)
  • Occipital lobe volume ( 31396565)
  • Optic disc size ( 31809533)
  • Pancreas volume ( 34128465)
  • Pulse pressure ( 27841878)
  • QT interval ( 29213071)
  • Red blood cell count ( 32888494 27863252)
  • Renal function-related traits (BUN) ( 22797727)
  • Serum urea levels ( 30808845)
  • Subcortical brain region volumes ( 25607358)
  • Systolic blood pressure ( 27841878 28739976 27618452 30487518)
  • Systolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Triglyceride levels ( 32203549 28334899 32154731)
  • Triglyceride levels in current drinkers ( 30698716)
  • Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • Triglycerides ( 24097068 25961943)
  • Waist circumference ( 25673412)
  • Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
  • Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist circumference adjusted for BMI in active individuals ( 28448500)
  • Waist circumference adjusted for BMI in non-smokers ( 28443625)
  • Waist circumference adjusted for body mass index ( 28552196 34021172 25673412 28448500)
  • Waist-hip index ( 34021172)
  • Waist-hip ratio ( 28552196 23563607 25673412 20935629)
  • Waist-to-hip ratio adjusted for BMI ( 28552196 34021172 26426971)
  • Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
  • Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971)
  • Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500)
  • Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500)
  • Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625)
  • Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
  • Waist-to-hip ratio adjusted for body mass index ( 28270201 25673412 28448500)
Interacting Genes 5 interacting genes: MARCHF2 RSPO1 RSPO2 RSPO3 RSPO4 4 interacting genes: HRAS LGR4 MTDH ZNRF3
Entrez ID 55366 84870
HPRD ID 05978 18181
Ensembl ID ENSG00000205213 ENSG00000146374
Uniprot IDs Q59ER8 Q9BXB1 Q9BXY4
PDB IDs 4KT1 4QXE 4QXF
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?