LGR4 and RSPO4

Number of citations of the paper that reports this interaction (PubMedID 29752411)
20

Data Source:
BioGRID (pull down, pull down, fluorescent resonance energy transfer)

		LGR4	RSPO4
Description		leucine rich repeat containing G protein-coupled receptor 4	R-spondin 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity	Protein Binding Heparin Binding
	Biological Process	Osteoblast Differentiation Negative Regulation Of Cytokine Production Hair Follicle Development Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Spermatogenesis Hormone-mediated Signaling Pathway Bone Mineralization Male Genitalia Development Circadian Regulation Of Gene Expression Negative Regulation Of Toll-like Receptor Signaling Pathway Intestinal Stem Cell Homeostasis Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Bone Remodeling Digestive Tract Development Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development Cell Differentiation Involved In Metanephros Development Metanephric Glomerulus Development Metanephric Nephron Tubule Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis	Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Nail Development
Pathways		Regulation of FZD by ubiquitination	Regulation of FZD by ubiquitination
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Bone mineral density ( 23644456) Bone mineral density (paediatric, skull) ( 24945404) Brain morphology (MOSTest) ( 32665545) Dental caries (decayed, missing and filled teeth) ( 31533690) Heel bone mineral density ( 30598549) Male-pattern baldness ( 28196072) Menarche (age at onset) ( 25231870) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Survival in pancreatic cancer ( 28470677) Urate levels in obese individuals ( 25811787)	Blood protein levels ( 30072576) Lean body mass ( 28552196) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321)
Interacting Genes		5 interacting genes: MARCHF2 RSPO1 RSPO2 RSPO3 RSPO4	15 interacting genes: ANKRD11 DHX57 GNG13 GPSM3 GUCD1 HGS KLHL38 LGR4 MAPK9 MKRN3 PIH1D2 STK16 USP20 ZNF330 ZNF77
Entrez ID		55366	343637
HPRD ID		05978	18788
Ensembl ID		ENSG00000205213	ENSG00000101282
Uniprot IDs		Q59ER8 Q9BXB1	Q2I0M5
PDB IDs		4KT1 4QXE 4QXF
Enriched GO Terms of Interacting Partners?
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