IFT57 and HIP1

Number of citations of the paper that reports this interaction (PubMedID 11788820)
77

Data Source:
HPRD (in vivo, two hybrid)

		IFT57	HIP1
Description		intraflagellar transport 57	huntingtin interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Centrosome Cilium Axoneme Intraciliary Transport Particle B Photoreceptor Connecting Cilium Ciliary Basal Body Dendrite Terminus Ciliary Tip	Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Intracellular Membrane-bounded Organelle Presynapse Postsynapse Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	DNA Binding Protein Binding	Epidermal Growth Factor Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Glutamate Receptor Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Neural Tube Closure Heart Looping Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Smoothened Signaling Pathway Intraciliary Transport Regulation Of Apoptotic Process Motile Cilium Assembly Negative Regulation Of Epithelial Cell Proliferation Left/right Pattern Formation Non-motile Cilium Assembly	Endocytosis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Filament Organization Regulation Of Endocytosis Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Protein Stabilization Positive Regulation Of Protein Kinase B Signaling Clathrin-dependent Endocytosis Apoptotic Signaling Pathway Neurotransmitter Receptor Transport Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Hedgehog 'off' state Intraflagellar transport Intraflagellar transport	Clathrin-mediated endocytosis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Bipolar disorder ( 31043756) Regular attendance at a religious group ( 29970889)	Age-related nuclear cataracts ( 24951543) Alcoholism (12-month weekly alcohol consumption) ( 21529783) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 26961502 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Fasting insulin ( 33402679) Interleukin-6 levels ( 22205395) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Systemic lupus erythematosus ( 26663301) White blood cell count (basophil) ( 27863252)
Interacting Genes		14 interacting genes: CASP8 CBLB CLTA EXOC5 HIP1 HTT IFT20 SKA2 SLC25A3 TERT UBXN10 WASHC1 YAF2 ZDHHC17	37 interacting genes: AP2A1 AP2B1 APAF1 CASP3 CASP8 CASP9 CFAP53 CLTA CLTB CLTC CYRIB DAZAP2 DVL2 EHHADH EIF6 FAM168A FBXO25 GLS2 HIP1R HTT IFT57 ITSN1 LITAF LNX1 MAP3K1 MAPK6 NECAP1 PFDN1 RAD23B REL RPRM RPS10 SMURF1 SYT17 TCEA2 TCEANC TFAP2A
Entrez ID		55081	3092
HPRD ID		09430	03461
Ensembl ID		ENSG00000114446	ENSG00000127946
Uniprot IDs		Q9NWB7	B4DK46 O00291
PDB IDs			2NO2 2QA7 3I00
Enriched GO Terms of Interacting Partners?
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