CLN6 and RIC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CLN6	RIC3
Description		CLN6 transmembrane ER protein	RIC3 acetylcholine receptor chaperone
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleolus Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Membrane Raft	Golgi Membrane Endoplasmic Reticulum Membrane Integral Component Of Membrane Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle Synapse
	Molecular Function	Protein Binding Lysophosphatidic Acid Binding Protein Homodimerization Activity Sulfatide Binding	Acetylcholine Receptor Binding Protein Folding Chaperone
	Biological Process	Ganglioside Metabolic Process Lysosome Organization Lysosomal Lumen Acidification Visual Perception Cholesterol Metabolic Process Protein Catabolic Process Glycosaminoglycan Metabolic Process Locomotion Involved In Locomotory Behavior Cellular Macromolecule Catabolic Process Positive Regulation Of Proteolysis	Protein Folding Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission, Cholinergic Protein Localization To Cell Surface Cellular Protein-containing Complex Assembly Positive Regulation Of Protein Localization To Cell Surface
Pathways
Drugs			Theophylline
Diseases
GWAS		Major depressive disorder ( 23377640) Restless legs syndrome ( 29029846)	Blood protein levels ( 30072576) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Malaria ( 31844061)
Interacting Genes		26 interacting genes: ARL13B CD79A CISD2 CLDN7 CLEC10A CPLX4 CREB3L1 CYBC1 EBAG9 EVI2B FAM209A FNDC9 GJA8 GORAB KIR2DL3 LIME1 LMNA LRRC25 RIC3 SLC22A23 SLC30A4 STX1A TEX264 TMEM139 TMEM237 TMPRSS2	16 interacting genes: BCL2L1 CACNA1C CLN6 FA2H FATE1 GOSR2 NINJ2 PRB1 STX12 STX7 TMBIM1 TMEFF2 TMEM11 TMEM86A TRAF3IP3 YIF1A
Entrez ID		54982	79608
HPRD ID		05991	17974
Ensembl ID		ENSG00000128973	ENSG00000166405
Uniprot IDs		A0A024R601 Q9NWW5	A0A0S2Z607 A0A0S2Z6D3 B7Z3Z0 D3DQU6 Q7Z5B4
PDB IDs
Enriched GO Terms of Interacting Partners?
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