SLC35F6 and ALDH2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SLC35F6	ALDH2
Description		solute carrier family 35 member F6	aldehyde dehydrogenase 2 family member
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Lysosomal Membrane Cytosol Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome	Mitochondrial Matrix Extracellular Exosome
	Molecular Function	Protein Binding Transmembrane Transporter Activity	Aldehyde Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Electron Transfer Activity Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (non-phosphorylating) Activity NAD Binding
	Biological Process	Positive Regulation Of Cell Population Proliferation Transmembrane Transport Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway	Carbohydrate Metabolic Process Alcohol Metabolic Process Ethanol Catabolic Process Electron Transport Chain
Pathways			Metabolism of serotonin Ethanol oxidation
Drugs			NADH Guanidine Disulfiram Daidzin Crotonaldehyde
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Alcohol consumption ( 21270382) Alcohol consumption (drinkers vs non-drinkers) ( 28485404 31959922) Alcohol consumption (drinks per week) ( 31959922) Alcohol consumption (max-drinks) ( 24277619 29460428) Alcohol dependence ( 24277619) Alcohol dependence symptom count ( 29460428) Aspartate aminotransferase levels ( 30718733) Blood pressure ( 21572416) Body mass index ( 26426971 24861553 28892062) Coffee consumption ( 31959922 29367735) Confectionary intake ( 33632354) Coronary artery disease ( 30402224 33020668) Coronary heart disease ( 23364394 21971053) Crohn's disease ( 26192919 28067908) Diastolic blood pressure ( 26390057 25249183) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Drinking behavior ( 23364009 21372407) Epilepsy ( 33913524) Esophageal cancer ( 19698717) Estimated glomerular filtration rate ( 31015462) Excessive alcohol consumption ( 33093602) Fish consumption ( 32895509) Fish intake frequency ( 31959922) Gamma glutamyl transferase levels ( 33093602) Gout ( 32238385) Gout (combined type) ( 32238385) Gout vs. Hyperuricemia ( 31289104) Green tea consumption ( 31959922) Height ( 31562340) Hematological and biochemical traits ( 20139978) Hemoglobin levels ( 32327693) hemolysis of donated blood (osmotic) ( 34014839) Hypertension ( 32709000 25249183) Inflammatory bowel disease ( 26192919 28067908) Intracranial aneurysm ( 22286173) Ischemic stroke ( 26708676) Ischemic stroke (small artery occlusion) ( 26708676) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin concentration ( 20139978) Metabolic syndrome ( 28371326) Milk consumption ( 31959922) Myocardial infarction ( 30226566 24916648) Natto consumption ( 31959922) Oral cavity and pharyngeal cancer ( 21437268) Primary biliary cholangitis ( 26394269) Psoriasis ( 25854761) Renal function-related traits (sCR) ( 22797727) Renal overload gout ( 32238385) Renal underexcretion gout ( 32238385) Response to alcohol consumption (flushing response) ( 24277619 29460428) Serum alpha1-antitrypsin levels ( 26174136) Serum uric acid levels ( 29408531 29124443) Small vessel stroke (CCSp classification) ( 32047268) Smoking behaviour (cigarettes smoked per day) ( 31089300) Stroke (ischemic) ( 23041239) Sweet taste preference ( 32572145) Systolic blood pressure ( 26390057 25249183) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tea consumption ( 33080986) Tofu consumption ( 31959922) Triglycerides ( 22171074 26582766) Type 2 diabetes ( 32499647) Urate levels ( 31578528) Waist-to-hip ratio adjusted for BMI ( 34054925) Yoghurt consumption ( 31959922)
Interacting Genes		22 interacting genes: ACP5 ACP6 ALDH2 AQP6 CBARP CERS4 FOLR1 GJA8 GPR152 KIAA0087 KIAA0232 MS4A7 NDUFA4L2 NSG2 OAT PSMG2 SEC11A SEPHS1 SERPINH1 TBPL1 TIMMDC1 TMEM14B	15 interacting genes: ALDH1A1 APP CRMP1 DENND10P1 EIF6 ERG28 HSPB2 HSPD1 HSPE1 IGSF21 OGT RPL13A SIRT3 SLC35F6 UNC119
Entrez ID		54978	217
HPRD ID		12808	00003
Ensembl ID		ENSG00000213699	ENSG00000111275
Uniprot IDs		Q8N357	A0A384NPN7 P05091
PDB IDs			1CW3 1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM 2ONM 2ONN 2ONO 2ONP 2VLE 3INJ 3INL 3N80 3N81 3N82 3N83 3SZ9 4FQF 4FR8 4KWF 4KWG 5L13
Enriched GO Terms of Interacting Partners?
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