ALDH2 and UNC119

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ALDH2	UNC119
Description		aldehyde dehydrogenase 2 family member	unc-119 lipid binding chaperone
Image
GO Annotations	Cellular Component	Mitochondrial Matrix Extracellular Exosome	Spindle Pole Centrosome Cytosol Intercellular Bridge Synapse Spindle Midzone
	Molecular Function	Aldehyde Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Electron Transfer Activity Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (non-phosphorylating) Activity NAD Binding	Protein Binding Lipid Binding
	Biological Process	Carbohydrate Metabolic Process Alcohol Metabolic Process Ethanol Catabolic Process Electron Transport Chain	Mitotic Cytokinesis Endocytosis Chemical Synaptic Transmission Nervous System Development Visual Perception Phototransduction Lipoprotein Transport Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis
Pathways		Metabolism of serotonin Ethanol oxidation
Drugs		NADH Guanidine Disulfiram Daidzin Crotonaldehyde
Diseases
GWAS		Alcohol consumption ( 21270382) Alcohol consumption (drinkers vs non-drinkers) ( 28485404 31959922) Alcohol consumption (drinks per week) ( 31959922) Alcohol consumption (max-drinks) ( 24277619 29460428) Alcohol dependence ( 24277619) Alcohol dependence symptom count ( 29460428) Aspartate aminotransferase levels ( 30718733) Blood pressure ( 21572416) Body mass index ( 26426971 24861553 28892062) Coffee consumption ( 31959922 29367735) Confectionary intake ( 33632354) Coronary artery disease ( 30402224 33020668) Coronary heart disease ( 23364394 21971053) Crohn's disease ( 26192919 28067908) Diastolic blood pressure ( 26390057 25249183) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Drinking behavior ( 23364009 21372407) Epilepsy ( 33913524) Esophageal cancer ( 19698717) Estimated glomerular filtration rate ( 31015462) Excessive alcohol consumption ( 33093602) Fish consumption ( 32895509) Fish intake frequency ( 31959922) Gamma glutamyl transferase levels ( 33093602) Gout ( 32238385) Gout (combined type) ( 32238385) Gout vs. Hyperuricemia ( 31289104) Green tea consumption ( 31959922) Height ( 31562340) Hematological and biochemical traits ( 20139978) Hemoglobin levels ( 32327693) hemolysis of donated blood (osmotic) ( 34014839) Hypertension ( 32709000 25249183) Inflammatory bowel disease ( 26192919 28067908) Intracranial aneurysm ( 22286173) Ischemic stroke ( 26708676) Ischemic stroke (small artery occlusion) ( 26708676) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin concentration ( 20139978) Metabolic syndrome ( 28371326) Milk consumption ( 31959922) Myocardial infarction ( 30226566 24916648) Natto consumption ( 31959922) Oral cavity and pharyngeal cancer ( 21437268) Primary biliary cholangitis ( 26394269) Psoriasis ( 25854761) Renal function-related traits (sCR) ( 22797727) Renal overload gout ( 32238385) Renal underexcretion gout ( 32238385) Response to alcohol consumption (flushing response) ( 24277619 29460428) Serum alpha1-antitrypsin levels ( 26174136) Serum uric acid levels ( 29408531 29124443) Small vessel stroke (CCSp classification) ( 32047268) Smoking behaviour (cigarettes smoked per day) ( 31089300) Stroke (ischemic) ( 23041239) Sweet taste preference ( 32572145) Systolic blood pressure ( 26390057 25249183) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tea consumption ( 33080986) Tofu consumption ( 31959922) Triglycerides ( 22171074 26582766) Type 2 diabetes ( 32499647) Urate levels ( 31578528) Waist-to-hip ratio adjusted for BMI ( 34054925) Yoghurt consumption ( 31959922)
Interacting Genes		15 interacting genes: ALDH1A1 APP CRMP1 DENND10P1 EIF6 ERG28 HSPB2 HSPD1 HSPE1 IGSF21 OGT RPL13A SIRT3 SLC35F6 UNC119	103 interacting genes: AAGAB ALDH2 AMOT ANKRD24 ANXA1 ANXA3 ANXA7 ARL15 ARL2 ARL3 ARL4D ASH2L BCR BRIX1 BTBD2 C16orf74 CBX8 CCL18 CD247 CD3E CD4 CDC42 CDKN1A CDKN2C CETN3 CKMT2 CKS2 COX17 CYB561D2 EIF2S2 ERH FKBPL FXYD6 FYN GIPC2 GSTM4 HCK HLA-DQA1 HMGB1 HSPB3 HSPE1 ID2 IL5RA ITSN1 KDM1A KRTAP1-3 KRTAP9-3 KRTAP9-8 LAMA4 LCK LIG4 LRIF1 LUC7L2 LYN MAP3K20 MAPK10 MAPK8IP2 MPHOSPH6 MRPS12 ORAI2 PAFAH1B3 PAPSS1 PCDHA4 PFN1 PHF10 PIN1 PLPP2 PPA1 PPP3CA PPP3CC PSMD11 PSMD2 PTPRS QTRT1 RAP1B RASSF6 RBPMS2 RCAN3 RCC1 RFC5 RGL2 RPA2 RPS6KA5 RUFY3 S100A4 S100A8 SAT1 SEPHS1 SERPINB9 SMN1 SULT1E1 TK1 TMEM200A TP53BP2 TP53I3 TP53INP1 TRDMT1 TSC22D1 UBE2B UBE2I UBQLN4 ZFP64 ZNF24
Entrez ID		217	9094
HPRD ID		00003	04927
Ensembl ID		ENSG00000111275	ENSG00000109103
Uniprot IDs		A0A384NPN7 P05091	K7EN86 Q13432
PDB IDs		1CW3 1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM 2ONM 2ONN 2ONO 2ONP 2VLE 3INJ 3INL 3N80 3N81 3N82 3N83 3SZ9 4FQF 4FR8 4KWF 4KWG 5L13	3GQQ 3RBQ 4GOJ 4GOK 5L7K 6H6A
Enriched GO Terms of Interacting Partners?
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